Diterpenoid Alkaloids from the Aerial Parts of <i>Aconitum flavum</i> Hand. -Mazz

doi:10.1007/s13659-021-00302-3

Natural Products and Bioprospecting

2021, Vol. 11

Issue (4) : 421-429 DOI: 10.1007/s13659-021-00302-3

ORIGINAL ARTICLES

Diterpenoid Alkaloids from the Aerial Parts of Aconitum flavum Hand. -Mazz

Na Zhang^1,2, Fan Xia¹, Song-Yu Li^1,2, Yin Nian¹, Li-Xin Wei³, Gang Xu¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2 University of Chinese Academy of Sciences, Beijing 100049, China;
3 Key Laboratory of Tibetan Medicine Research and Qinghai Provincial Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, Qinghai, China

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Abstract Sixteen diterpenoid alkaloids (DAs), including six aconitine-type alkaloids (5 and 9-13), seven 7,17-seco-aconitine-type alkaloids (1-4, 6-8), two napelline-type alkaloids (14 and 15) as well as one veatchine-type alkaloid (16), were isolated from the aerial parts of Aconitum fl avum Hand.-Mazz. In which, flavumolines A-D (1-4) were four new ones, and flavumoline E (5) was reported as natural compound for the first time. Their chemical structures were elucidated by the analysis of extensive spectroscopic data. The inhibitory activities of these isolates on Ca_v3.1 low voltage-gated Ca²⁺ channel, NO production in LPS-activated RAW264.7cells, five human tumor cell lines, as well as acetylcholinesterase (AChE) were tested.

Keywords Aconitum fl avum Hand.-Mazz Diterpenoid alkaloids Bioactivity

Fund:The work was financially supported by the Second Tibetan Plateau Scientific Expedition and Research (STEP) program (2019QZKK0502), State Key Laboratory of Phytochemistry and Plant Resources in West China (P2017-KF02 and P2019-ZZ05), and the Natural Sciences Foundation of Yunnan Province (2019FA003).

Corresponding Authors: Gang Xu E-mail: xugang008@mail.kib.ac.cn

Issue Date: 30 July 2021

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Na Zhang,Fan Xia,Song-Yu Li, et al. Diterpenoid Alkaloids from the Aerial Parts of Aconitum flavum Hand. -Mazz[J]. Natural Products and Bioprospecting, 2021, 11(4): 421-429.

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http://npb.kib.ac.cn/EN/10.1007/s13659-021-00302-3 OR http://npb.kib.ac.cn/EN/Y2021/V11/I4/421

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