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Isochromophilones from an endophytic fungus Diaporthe sp. |
| Le-Yun ZANG, Wei WEI, Ting WANG, Ye GUO, Ren-Xiang TAN, Hui-Ming GE |
| Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing 210093, China |
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Abstract Three new azaphilone compounds, isochromophilones X-XII(1-3), together with two known ones sclerotioramine(4) and isochromophilone VI(5) were isolated from the cultures of an endophytic fungus Diaporthe sp. The structures were elucidated by extensive HRESIMS and NMR spectroscopic analyses. All compounds were tested for their cytotoxicities against five human cancer cell lines by MTT method, among which compound 1 showed moderate inhibitory effects on these cell lines. This was the first report of azaphilones isolated from Diaporthe sp.
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| Keywords
azaphilone
endophyte
Diaporthe sp.
cytotoxicity
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| Fund:This work was co-financed by National Natural Science Foundation of China(81121062, 21132004, 90813036, and 81172948), MOE(NCET-10-0477), and Jiangsu Provincial Government(BK2009010). |
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Issue Date: 11 February 2018
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