Total Synthesis of Lignan Lactone(-)-Hinokinin

doi:10.1007/s13659-015-0073-3

Natural Products and Bioprospecting

2015, Vol. 5

Issue (5) : 255-261 DOI: 10.1007/s13659-015-0073-3

Original article

Total Synthesis of Lignan Lactone(-)-Hinokinin

Qi-Long Zhou¹, Hui-Jing Wang¹, Pei Tang¹, Hao Song², Yong Qin²

1. Innovative Drug Research Centre, Chongqing University, Chongqing 401331, China;
2. Key Laboratory of Drug Targeting and Drug Delivery Systems of the Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China

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Abstract This research paper is aimed at studying the total synthesis of pharmacologically active lignan(-)-hinokinin. The synthesis features a three-step cascade reaction involving highly stereoselective Michael addition, anion-oxidative hydroxylation, and oxygen anion cyclization to construct the pivotal butyrolactonimidate intermediate.

Keywords Lignan Hinokinin Total synthesis Cascade reaction

Fund:We acknowledge grant supports from Chongqing University, and the Fundamental Research Funds for the Central Universities(Project No. 0236015202004).

Issue Date: 11 February 2018

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Qi-Long Zhou,Hui-Jing Wang,Pei Tang, et al. Total Synthesis of Lignan Lactone(-)-Hinokinin[J]. Natural Products and Bioprospecting, 2015, 5(5): 255-261.

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http://npb.kib.ac.cn/EN/10.1007/s13659-015-0073-3 OR http://npb.kib.ac.cn/EN/Y2015/V5/I5/255

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