Four new lignans from the leaves and stems of <i>Schisandra propinqua</i> var. <i>sinensis</i>

doi:10.1007/s13659-013-0017-8

Natural Products and Bioprospecting

2013, Vol. 3

Issue (2) : 56-60 DOI: 10.1007/s13659-013-0017-8

Regular Article

Four new lignans from the leaves and stems of Schisandra propinqua var. sinensis

Shan-Zhai SHANG^a,c, Ying-Shan HAN^b, Yi-Ming SHI^a,c, Xue DU^a, Cheng-Qin LIANG^a,c, Mark A. WAINBERG^b, Zhong-Hua GAO^a,c, Wei-Lie XIAO^a, Han-Dong SUN^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b McGill University AIDS Centre, Lady Davis for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada;
c University of Chinese Academy of Sciences, Beijing 100049, China

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Abstract Four new tetrahydrofuran lignans, schpropinrins A-D (1-4), together with five known ones, were isolated from the leaves and stems of Schisandra propinqua var. sinensis. Their structures, including absolute configurations, were characterized by means of spectroscopic analysis and ECD calculation. Compounds 1-4 featured a ketal or hemiketal substructure at C-7 and all of the isolates were tested for their anti-HIV integrase activity.

Keywords Schisandra propinqua var. sinensi schpropinrins lignan anti-human immunodeficiency virus integrase activity

Fund:This project was supported financially by the NSFC (No. 20802082 and 30830115), the projects from the Chinese Academy of Sciences (KSCX2-EW-Q-10 and KSCX1-YW-R-24), the Major State Basic Research Development Program of China (No. 2009CB522303 and 2009CB940900), the Natural Science Foundation of Yunnan Province (No. 2012FB178), and a part of this work was financially supported by the Canadian Institutes for Health Research.

Issue Date: 11 February 2018

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	Shan-Zhai SHANG
	Ying-Shan HAN
	Yi-Ming SHI
	Xue DU
	Cheng-Qin LIANG
	Mark A. WAINBERG
	Zhong-Hua GAO
	Wei-Lie XIAO
	Han-Dong SUN

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Shan-Zhai SHANG,Ying-Shan HAN,Yi-Ming SHI, et al. Four new lignans from the leaves and stems of Schisandra propinqua var. sinensis[J]. Natural Products and Bioprospecting, 2013, 3(2): 56-60.

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http://npb.kib.ac.cn/EN/10.1007/s13659-013-0017-8 OR http://npb.kib.ac.cn/EN/Y2013/V3/I2/56

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