Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from <i>Rauvolfia tetraphylla</i>

doi:10.1007/s13659-015-0074-2

Natural Products and Bioprospecting

2015, Vol. 5

Issue (5) : 247-253 DOI: 10.1007/s13659-015-0074-2

Original article

Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla

Yuan Gao, Dong-Sheng Zhou, Ping Hai, Yan Li, Fei Wang

1. BioBioPha Co., Ltd., Kunming 650201, People's Republic of China;
2. Department of Chemical Engineering, Yibin University, Yibin 644000, People's Republic of China

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Abstract Five new hybrid monoterpenoid indole alkaloids bearing an unusual 2, 2-dimethyl-4-oxopiperidin-6-yl moiety, namely rauvotetraphyllines F-H(1, 3, 4), 17-epi-rauvotetraphylline F(2) and 21-epi-rauvotetraphylline H(5), were isolated from the aerial parts of Rauvolfia tetraphylla. Their structures were established by extensive spectroscopic analysis. The new alkaloids were evaluated for their cytotoxicity in vitro against five human cancer cell lines.

Keywords Rauvolfia tetraphylla Monoterpenoid indole alkaloid Rauvotetraphylline

Fund:This work was financially supported by "Largescale Compound Library" Project of National Development and Reform Commission of China.

Issue Date: 11 February 2018

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Yuan Gao,Dong-Sheng Zhou,Ping Hai, et al. Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla[J]. Natural Products and Bioprospecting, 2015, 5(5): 247-253.

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http://npb.kib.ac.cn/EN/10.1007/s13659-015-0074-2 OR http://npb.kib.ac.cn/EN/Y2015/V5/I5/247

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