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Steroids and Sesquiterpenes From Cultures of the Fungus Phellinus igniarius |
| Rong-Hua Yin1,2, Zhen-Zhu Zhao1,2, Xu Ji1, Ze-Jun Dong1, Zheng-Hui Li1, Tao Feng1, Ji-Kai Liu1 |
1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2. University of Chinese Academy of Sciences, Beijing 100049, China |
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Abstract Two new steroids, 3α, 17α, 19, 20-tetrahydroxy-4α-methylpregn-8-ene(1) and 3α, 12α, 17α, 20-tetrahydroxy-4α-methylpregn-8-ene(2) and three new sesquiterpenoids, 12-hydroxy-α-cadinol(3), 3α, 12-dihydroxy-δ-cadinol(4), and 3α, 6α-dihydroxyspiroax-4-ene(5), have been isolated from cultures of the fungus Phellinus igniarius. Their structures were characterized based on extensive spectroscopic data. In preliminary in vitro assays, compounds 3 and 4 exhibited the vascular-activities against phenylephrine-induced vasoconstriction with the relaxing rates of 11.0% and 7.0% at 3×10-4 M, respectively.
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| Keywords
Pregnene steroids
Sesquiterpenes
Phellinus igniarius
Cytotoxicity
Vascular-activities
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| Fund:This project was supported by the National Natural Sciences Foundation of China(U1132607, 81102346) and Natural Sciences Foundation of Yunnan Province(2011FB099). |
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Issue Date: 11 February 2018
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