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Lactam Triterpenoids from the Bark of Toona sinensis |
| Qian-Qian Meng1,2, Xing-Rong Peng1,3, Shuang-Yang Lu1,2, Luo-Sheng Wan1,3, Xia Wang1,2, Jin-Run Dong1,2, Rui Chu1,2, Lin Zhou1,3, Xiao-Nian Li1,3, Ming-Hua Qiu1,2,3 |
1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2. University of the Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3. Yunnan University of Traditional Chinese Medicine, Kunming 650500, People's Republic of China |
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Abstract Three new limonoid-type triterpenoids, namely toonasins A-C (1-3) with a rare lactam E ring, along with six known compounds (4-9) were isolated from the barks of Toona sinensis. The structures of new compounds were elucidated by interpretation of spectroscopic data, and the relative configuration of compound 1 was further characterized by X-ray crystallographic analyses. The isolated compounds were evaluated for their cytotoxic activities against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW480), and compounds 3 and 5 showed weak cytotoxicities.
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| Keywords
Toona sinensis
Limonoids
Lactam triterpenoids
Cytotoxicity
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| Fund:This project was financially supported by Major Program of the National Knowledge Innovation of CAS (No.KSCX2-YW-G-038);and the Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China (P2015-ZZ09);Authors also were particularly grateful to Research Group of Prof.Yan Li for bioassay tests |
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Issue Date: 08 February 2018
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