Clerodane Diterpenoids with Anti-hyperglycemic Activity from <i>Tinospora crispa</i>

doi:10.1007/s13659-016-0109-3

Natural Products and Bioprospecting

2016, Vol. 6

Issue (5) : 247-255 DOI: 10.1007/s13659-016-0109-3

Original article

Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa

Yuan Gao^1,2,3, Yan-Fen Niu^1,4,5, Fei Wang^1,3,4, Ping Hai^2,3, Fang Wang¹, Yin-Dong Fang³, Wen-Yong Xiong¹, Ji-Kai Liu^1,6

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China;
2. Department of Chemical Engineering, Yibin University, Yibin 644000, People's Republic of China;
3. BioBioPha Co., Ltd, Kunming 650201, People's Republic of China;
4. Graduate University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
5. Yunnan University, Kunming 650091, People's Republic of China;
6. School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China

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Abstract Four new clerodane diterpenoids, tinosporols A-C (2-4) and tinosporoside A (5), together with six known analogues were isolated from the vines of Tinospora crispa. Their structures were established by extensive spectroscopic analysis. The relative configuration at C-12 in the known diterpenoid borapetoside E (1), the major component of the plant, was firstly established with the aid of molecular model. Compound 1 significantly reduced serum glucose levels at dosedependent manners in alloxan-induced hyperglycemic mice and db/db type 2 diabetic mice.

Keywords Anti-hyperglycemia

Issue Date: 08 February 2018

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	Yuan Gao
	Yan-Fen Niu
	Fei Wang
	Ping Hai
	Fang Wang
	Yin-Dong Fang
	Wen-Yong Xiong
	Ji-Kai Liu

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Yuan Gao,Yan-Fen Niu,Fei Wang, et al. Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa[J]. Natural Products and Bioprospecting, 2016, 6(5): 247-255.

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http://npb.kib.ac.cn/EN/10.1007/s13659-016-0109-3 OR http://npb.kib.ac.cn/EN/Y2016/V6/I5/247

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