| ORIGINAL ARTICLES |
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Gastrodinol derivatives and prenylated flavones from the flower branch of Gastrodia elata |
| Shi-Hui Qin1,2, Zhi-Lan Li1, Liu Yang1, Jiang-Miao Hu1 |
1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, China;
2 College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China |
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Abstract Based on the research progress and traditional usage with whole herbal of the TCM "Tianma", chemical studies herein on the flower branch of Gastrodia elata were carried out in-depth and got 13 compounds including the gastrodinols (1–4), the flavonoid morins (5–8, 11–12), together with the specialist mulberrofurans (9, 13) and gastrodiamide (10) for the first time from the species. The antibacterial and cholinesterase inhibitory activities were then evaluated and the results showed that compounds 5, 11, 12, 13 have good activity against anti-methicillin-resistant Staphylococcus aureus, and compounds 9, 13 had good acetylcholinesterase inhibitory activity. All these results provide new chemical composition for better understanding the traditional application of "Tianma" and for exploring new pharmacological ingredients.
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| Keywords
Gastrodia elata
Orchidaceae
Gastrodinol
Isoprene-flavonoids
Mulberrofurans
Gastrodiamide
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| Fund:This work was supported by grants from Poverty alleviation through science and technology projects of Chinese Academy of Sciences (KFJ-FP-201905). |
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Corresponding Authors:
Jiang-Miao Hu,E-mail:hujiangmiao@mail.kib.ac.cn
E-mail: hujiangmiao@mail.kib.ac.cn
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Issue Date: 14 June 2024
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