Melatonin Receptors Agonistic Activities of Phenols from <i>Gastrodia elata</i>

doi:10.1007/s13659-019-0213-2

Natural Products and Bioprospecting

2019, Vol. 9

Issue (4) : 297-302 DOI: 10.1007/s13659-019-0213-2

ORIGINAL ARTICLES

Melatonin Receptors Agonistic Activities of Phenols from Gastrodia elata

Si-Yue Chen^1,2, Chang-An Geng¹, Yun-Bao Ma¹, Ji-Jun Chen^1,2

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Yunnan Key Laboratory of Natural Medicinal Chemistry, Chinese Academy of Sciences, Kunming 650201, China;
2 University of Chinese Academy of Sciences, Beijing 100049, China

Abstract
References
Related Articles
Metrics

Download: PDF(3914 KB) HTML ()
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks

Abstract Gastrodia elata is a famous traditional Chinese herb with medicinal and edible application. In this study, three new polybenzyls, gastropolybenzylols G-I (1-3) were isolated from the EtOAc extract of G. elata. Their structures were identified by extensive spectroscopic analyses involving HRESIMS, UV, IR, 1D and 2D NMR. Compound 1 showed agonistic effects on MT₁ and MT₂ receptors with agonistic rates of 55.91±4.84% and 165.13±5.65% at the concentration of 0.5 mM, respectively, and an EC₅₀ value of 76.24 μM on MT₂ receptor.

Keywords Gastrodia elata Gastropolybenzylols Melatonin receptors

Fund:This work was supported by the Program of Yunling Scholar, the Youth Innovation Promotion Association, CAS (2013252), and the Applied Basic Research Programs of Yunnan Province (2017FB137).

Corresponding Authors: Ji-Jun Chen E-mail: chenjj@mail.kib.ac.cn

Issue Date: 09 August 2019

	Service

	E-mail this article
	E-mail Alert
	RSS
	Articles by authors

	Si-Yue Chen
	Chang-An Geng
	Yun-Bao Ma
	Ji-Jun Chen

Trendmd:

Cite this article:

Si-Yue Chen,Chang-An Geng,Yun-Bao Ma, et al. Melatonin Receptors Agonistic Activities of Phenols from Gastrodia elata[J]. Natural Products and Bioprospecting, 2019, 9(4): 297-302.

URL:

http://npb.kib.ac.cn/EN/10.1007/s13659-019-0213-2 OR http://npb.kib.ac.cn/EN/Y2019/V9/I4/297

1. L.M. Ojemann, W.L. Nelson, D.S. Shin, A.O. Rowe, R. Buchanan, Epilepsy Behav. 8, 376-383 (2006)
2. Y. Zhang, M. Li, R. Kang, J. Shi, G. Liu, J. Zhang, Pharmacol. Biochem. Behav. 102, 450-457 (2012)
3. Y. Shi, J.W. Dong, L.N. Tang, R.X. Kang, J.G. Shi, J.J. Zhang, Pharmacol. Biochem. Behav. 126, 146-151 (2014)
4. J.W. Jung, B.H. Yoon, H.R. Oh, J.H. Ahn, S.Y. Kim, S.Y. Park, J.F. Ryu, Biol. Pharm. Bull. 29, 261-265 (2006)
5. B.H. Zhou, X.J. Li, M. Liu, Z. Wu, X.M. Hu, Fitoterapia 77, 592-594 (2006)
6. S. Lin, W. Chen, K. Lu, P. Chen, S. Hsieh, T. Pan, S. Chen, L. Sheen, J. Agric. Food Chem. 62, 10493-10503 (2014)
7. P. Chen, C. Hsieh, K. Su, Y. Hou, H. Chiang, L. Sheen, Am. J. Chin. Med. 37, 1113-1124 (2009)
8. C. Hsieh, J. Lin, S. Chiang, S. Su, N. Tang, G. Lin, I. Lin, C. Liu, C. Hsiang, J. Chen, T. Ho, J. Ethnopharmacol. 109, 241-247 (2007)
9. J.H. Ha, D.U. Lee, J.T. Lee, J.S. Kim, C.S. Yong, J.A. Kim, J.S. Ha, K. Huh, J. Ethnopharmacol. 73, 329-333 (2000)
10. D.S.H.L. Kim, J. Kim, Y.S. Han, J. Altern. Complem. Med. 13, 333-340 (2007)
11. Y. Hu, C. Li, W. Shen, Neuropathology 34, 370-377 (2014)
12. O. Lee, K. Kim, C. Han, Y. Kim, H. Hong, Int. J. Mol. Sci. 13, 698-709 (2012)
13. J. Heo, S. Woo, M. Son, J. Park, W. Choi, K. Chang, S. Kim, E. Yoon, Y. Kim, H.M. Shin, S. Lee, Oncol. Rep. 18, 849-853 (2007)
14. H. Qiu, W. Tang, X. Tong, K. Ding, J. Zuo, Carbohydr. Res. 342, 2230-2236 (2007)
15. X. Tong, H. Qiu, X. Zhang, L. Shi, G. Wang, F. Ji, H. Ding, W. Tang, K. Ding, J. Zuo, Acta Pharmacol. Sin. 31, 585-592 (2010)
16. J.Y. Lee, Y.W. Jang, H.S. Kang, H. Moon, S.S. Sim, C.J. Kim, Arch. Pharm. Res. 29, 849-858 (2006)
17. S.M. Hwang, Y.J. Lee, D.G. Kang, H.S. Lee, Am. J. Chin. Med. 37, 395-406 (2009)
18. X.D. Yang, J. Zhu, R. Yang, J.P. Liu, L. Li, H.B. Zhang, Nat. Prod. Res. 21, 180-186 (2007)
19..G. Shi, N.H. Chen, Y.N. Wang, Y.H. Yuan, S. Lin, M.M. Wu, Q.L. Guo, C.G. Zhu, China Patent CN103420805A, Dec 2013
20. J.Y. Huang, Y.H. Yuan, J.Q. Yan, Y.N. Wang, S.F. Chu, C.G. Zhu, Q.L. Guo, S.J. Gong, N.H. Chen, Acta Pharmacol. Sin. 37, 74-83 (2016)
21. X.L. Zhang, Y.H. Yuan, Q.H. Shao, Z.Z. Wang, C.G. Zhu, J.G. Shi, K.L. Ma, X. Yan, N.H. Chen, Toxicol. Lett. 271, 74-83 (2017)
22. Q.H. Shao, X.L. Zhang, Y. Chen, C.G. Zhu, J.G. Shi, Y.H. Yuan, N.H. Chen, Mol. Immunol. 99, 115-123 (2018)
23. H. Taguchi, Y. Heihachiro, Y. Itiro, K. Yamasaki, I.H. Kim, Chem. Pharm. Bull. 29, 55-62 (1981)
24. S.G. Kim, K.N. Chung, S.B. Yang, J. Org. Chem. 52, 3917-3919 (1987)
25. J. Zhou, X.Y. Pu, Y.B. Yang, Sci. Bull. 18, 1118-1120 (1981)
26. Z.F. Li, Y.W. Wang, H. Ouyang, Y. Lu, Y. Qiu, Y. Feng, H. Jiang, X. Zhou, S. Yang, J. Chromatogr. B 988, 45-52 (2015)
27. Y.L. Zhang, L.H. Lai, S.M. Wang, Chin. J. Biotechnol. 25, 457-463 (2009)
28. Y. Hasegawa, J.R. Erickson, G.J. Goddard, S.X. Yu, S.Y. Liu, K.W. Cheng, A. Eder, K. Bandoh, J. Aoki, R. Jarosz, A.D. Schrier, K.R. Lynch, G.B. Mills, X.J. Fang, J. Biol. Chem. 278, 11962-11969 (2003)

No related articles found!

Viewed

Full text

Abstract

Cited

Shared

Discussed