Natural Products in Cancer Therapy: Past, Present and Future

doi:10.1007/s13659-020-00293-7

Natural Products and Bioprospecting

2021, Vol. 11

Issue (1) : 5-13 DOI: 10.1007/s13659-020-00293-7

REVIEW

Natural Products in Cancer Therapy: Past, Present and Future

Min Huang^1,2, Jin-Jian Lu³, Jian Ding^1,2

1 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China;
2 University of Chinese Academy of Sciences, Beijing, China;
3 State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China

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Abstract Natural products, with remarkable chemical diversity, have been extensively investigated for their anticancer potential for more than a half-century. The collective efforts of the community have achieved the tremendous advancements, bringing natural products to clinical use and discovering new therapeutic opportunities, yet the challenges remain ahead. With remarkable changes in the landscape of cancer therapy and growing role of cutting-edge technologies, we may have come to a crossroads to revisit the strategies to understand nature products and to explore their therapeutic utility. This review summarizes the key advancements in nature product-centered cancer research and calls for the implementation of systematic approaches, new pharmacological models, and exploration of emerging directions to revitalize natural products search in cancer therapy.

Keywords Natural products Cancer therapy Drug discovery Antibody-drug conjugates Combination therapy

Fund:The authors thank Zi-Han Ye and Wei-Bang Yu for the assistance in preparing the figures.

Corresponding Authors: Jian Ding E-mail: jding@simm.ac.cn

Issue Date: 11 March 2021

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Min Huang,Jin-Jian Lu,Jian Ding. Natural Products in Cancer Therapy: Past, Present and Future[J]. Natural Products and Bioprospecting, 2021, 11(1): 5-13.

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http://npb.kib.ac.cn/EN/10.1007/s13659-020-00293-7 OR http://npb.kib.ac.cn/EN/Y2021/V11/I1/5

1. D.J. Newman, G.M. Cragg, J. Nat. Prod. 83, 770-803 (2020)
2. M.Y. Huang, L.L. Zhang, J. Ding, J.J. Lu, Chin. Med. 13, 35 (2018)
3. M.E. Wall, M.C. Wani, Cancer Res. 55, 753-760 (1995)
4. M.E. Wall, Med. Res. Rev. 18, 299-314 (1998)
5. M.A. Sanz, P. Fenaux, M.S. Tallman, E.H. Estey, B. Lowenberg, T. Naoe, E. Lengfelder, H. Dohner, A.K. Burnett, S.J. Chen, V. Mathews, H. Iland, E. Rego, H. Kantarjian, L. Ades, G. Avvisati, P. Montesinos, U. Platzbecker, F. Ravandi, N.H. Russell, F. Lo-Coco, Blood 133, 1630-1643 (2019)
6. E. Martino, S. Della Volpe, E. Terribile, E. Benetti, M. Sakaj, A. Centamore, A. Sala, S. Collina, Bioorg. Med. Chem. Lett. 27, 701-707 (2017)
7. N.H. Oberlies, D.J. Kroll, J. Nat. Prod. 67, 129-135 (2004)
8. Y. Pommier, Nat. Rev. Cancer 6, 789-802 (2006)
9. M.E. Wall, M.C. Wani, J Ethnopharmacol. 51, 239-253 (1996)
10. M. Huang, H. Gao, Y. Chen, H. Zhu, Y. Cai, X. Zhang, Z. Miao, H. Jiang, J. Zhang, H. Shen, L. Lin, W. Lu, J. Ding, Clin. Cancer Res. 13, 1298-1307 (2007)
11. W.J. Gradishar, Expert. Opin. Pharmacother. 7, 1041-1053 (2006)
12. W.J. Gradishar, S. Tjulandin, N. Davidson, H. Shaw, N. Desai, P. Bhar, M. Hawkins, J. O'Shaughnessy, J. Clin. Oncol. 23, 7794-7803 (2005)
13. T.D. Zhang, Y.S. Li, J. Integr. Tradit. West Med. 4, 19 (1984)
14. H.D. Sun, L. Ma, H.X. Hu, T.D. Zhang, Chin. J. Integr. Med. 12, 170-171 (1992)
15. S.J. Chen, G.B. Zhou, X.W. Zhang, J.H. Mao, H. de The, Z. Chen, Blood 117, 6425-6437 (2011)
16. V. Lallemand-Breitenbach, J. Zhu, Z. Chen, H. de The, Trends Mol. Med. 18, 36-42 (2012)
17. P. Zhang, S.Y. Wang, X.H. Hu, Chin. J. Hematol. 17, 58-60 (1996)
18. B.L. Powell, B. Moser, W. Stock, R.E. Gallagher, C.L. Willman, R.M. Stone, J.M. Rowe, S. Coutre, J.H. Feusner, J. Gregory, S. Couban, F.R. Appelbaum, M.S. Tallman, R.A. Larson, Blood 116, 3751-3757 (2010)
19. C. Niu, H. Yan, T. Yu, H.P. Sun, J.X. Liu, X.S. Li, W. Wu, F.Q. Zhang, Y. Chen, L. Zhou, J.M. Li, X.Y. Zeng, R.R. Yang, M.M. Yuan, M.Y. Ren, F.Y. Gu, Q. Cao, B.W. Gu, X.Y. Su, G.Q. Chen, S.M. Xiong, T.D. Zhang, S. Waxman, Z.Y. Wang, Z. Chen, J. Hu, Z.X. Shen, S.J. Chen, Blood 94, 3315-3324 (1999)
20. Z.X. Shen, Z.Z. Shi, J. Fang, B.W. Gu, J.M. Li, Y.M. Zhu, J.Y. Shi, P.Z. Zheng, H. Yan, Y.F. Liu, Y. Chen, Y. Shen, W. Wu, W. Tang, S. Waxman, H. De The, Z.Y. Wang, S.J. Chen, Z. Chen, Proc. Natl. Acad. Sci. U S A 101, 5328-5335 (2004)
21. H. de The, Z. Chen, Nat. Rev. Cancer 10, 775-783 (2010)
22. M. Jeanne, V. Lallemand-Breitenbach, O. Ferhi, M. Koken, M. Le Bras, S. Duffort, L. Peres, C. Berthier, H. Soilihi, B. Raught, H. de The, Cancer Cell 18, 88-98 (2010)
23. X.W. Zhang, X.J. Yan, Z.R. Zhou, F.F. Yang, Z.Y. Wu, H.B. Sun, W.X. Liang, A.X. Song, V. Lallemand-Breitenbach, M. Jeanne, Q.Y. Zhang, H.Y. Yang, Q.H. Huang, G.B. Zhou, J.H. Tong, Y. Zhang, J.H. Wu, H.Y. Hu, H. de The, S.J. Chen, Z. Chen, Science 328, 240-243 (2010)
24. V. Lallemand-Breitenbach, M. Jeanne, S. Benhenda, R. Nasr, M. Lei, L. Peres, J. Zhou, J. Zhu, B. Raught, H. de The, Nat. Cell Biol. 10, 547-555 (2008)
25. M.H. Tatham, M.C. Geoffroy, L. Shen, A. Plechanovova, N. Hattersley, E.G. Jaffray, J.J. Palvimo, R.T. Hay, Nat. Cell Biol. 10, 538-546 (2008)
26. A. Beck, L. Goetsch, C. Dumontet, N. Corvaia, Nat. Rev. Drug Discov. 16, 315-337 (2017)
27. M. Abdollahpour-Alitappeh, M. Lotfinia, T. Gharibi, J. Mardaneh, B. Farhadihosseinabadi, P. Larki, B. Faghfourian, K.S. Sepehr, K. Abbaszadeh-Goudarzi, G. Abbaszadeh-Goudarzi, B. Johari, M.R. Zali, N. Bagheri, J. Cell Physiol. 234, 5628-5642 (2019)
28. A. Mullard, Nat. Rev. Drug Discov. 12, 329-332 (2013)
29. L.G. Lin, H. Xie, H.L. Li, L.J. Tong, C.P. Tang, C.Q. Ke, Q.F. Liu, L.P. Lin, M.Y. Geng, H. Jiang, W.M. Zhao, J. Ding, Y. Ye, J. Med. Chem. 51, 4419-4429 (2008)
30. S.P. Yang, X.W. Zhang, J. Ai, L.S. Gan, J.B. Xu, Y. Wang, Z.S. Su, L. Wang, J. Ding, M.Y. Geng, J.M. Yue, J. Med. Chem. 55, 8183-8187 (2012)
31. M.H. Li, Z.H. Miao, W.F. Tan, J.M. Yue, C. Zhang, L.P. Lin, X.W. Zhang, J. Ding, Clin. Cancer Res. 10, 8266-8274 (2004)
32. B. Yu, M.H. Li, W. Wang, Y.Q. Wang, Y. Jiang, S.P. Yang, J.M. Yue, J. Ding, Z.H. Miao, J. Mol. Med. 90, 971-981 (2012)
33. X. Zhu, C. Yuan, C. Tian, C. Li, F. Nie, X. Song, R. Zeng, D. Wu, X. Hao, L. Li, J. Biol. Chem. 293, 5335-5344 (2018)
34. Y. Li, M. Xu, X. Ding, C. Yan, Z. Song, L. Chen, X. Huang, X. Wang, Y. Jian, G. Tang, C. Tang, Y. Di, S. Mu, X. Liu, K. Liu, T. Li, Y. Wang, L. Miao, W. Guo, X. Hao, C. Yang, Nat. Cell. Biol. 18, 1065-1077 (2016)
35. G. Germano, R. Frapolli, M. Simone, M. Tavecchio, E. Erba, S. Pesce, F. Pasqualini, F. Grosso, R. Sanfilippo, P.G. Casali, A. Gronchi, E. Virdis, E. Tarantino, S. Pilotti, A. Greco, M. Nebuloni, C.M. Galmarini, J.C. Tercero, A. Mantovani, M. D'Incalci, P. Allavena, Cancer Res. 70, 2235-2244 (2010)
36. R.Y. Huang, W.T. Chen, T. Kurtan, A. Mandi, J. Ding, J. Li, X.W. Li, Y.W. Guo, Future Med. Chem. 8, 17-27 (2016)
37. C.L. Gao, G.G. Hou, J. Liu, T. Ru, Y.Z. Xu, S.Y. Zhao, H. Ye, L.Y. Zhang, K.X. Chen, Y.W. Guo, T. Pang, X.W. Li, Angew. Chem. Int. Ed. Engl. 59, 2429-2439 (2020)
38. L.R. Whitby, R.S. Obach, G.M. Simon, M.M. Hayward, B.F. Cravatt, ACS Chem. Biol. 12, 2040-2050 (2017)
39. J. Chang, Y. Kim, H.J. Kwon, Nat. Prod. Rep. 33, 719-730 (2016)
40. D.K. Nomura, T.J. Maimone, Curr. Top Microbiol. Immunol. 420, 351-374 (2019)
41. S. Pan, H. Zhang, C. Wang, S.C. Yao, S.Q. Yao, Nat. Prod. Rep. 33, 612-620 (2016)
42. M.H. Wright, S.A. Sieber, Nat. Prod. Rep. 33, 681-708 (2016)
43. J.N. Spradlin, X. Hu, C.C. Ward, S.M. Brittain, M.D. Jones, L. Ou, M. To, A. Proudfoot, E. Ornelas, M. Woldegiorgis, J.A. Olzmann, D.E. Bussiere, J.R. Thomas, J.A. Tallarico, J.M. McKenna, M. Schirle, T.J. Maimone, D.K. Nomura, Nat. Chem. Biol. 15, 747-755 (2019)
44. E.A. Grossman, C.C. Ward, J.N. Spradlin, L.A. Bateman, T.R. Huffman, D.K. Miyamoto, J.I. Kleinman, D.K. Nomura, Cell Chem. Biol. 24, 1368-1376 (2017)
45. S.K. Yan, R.H. Liu, H.Z. Jin, X.R. Liu, J. Ye, L. Shan, W.D. Zhang, Chin. J. Nat. Med. 13, 3-21 (2015)
46. D.C. Swinney, Clin. Pharmacol. Ther. 93, 299-301 (2013)
47. D. Hanahan, R.A. Weinberg, Cell 144, 646-674 (2011)
48. W. Du, O. Elemento, Oncogene 34, 3215-3225 (2015)
49. J. Bajorath, S. Kearnes, W.P. Walters, N.A. Meanwell, G.I. Georg, S. Wang, J. Med. Chem. 63, 8651-8652 (2020)
50. R. Zhang, X. Li, X. Zhang, H. Qin, W. Xiao, Nat. Prod. Rep. (2020). https://doi.org/10.1039/d0np00043d
51. L. Zitvogel, M. Ayyoub, B. Routy, G. Kroemer, Cell 165, 276-287 (2016)
52. V. Gopalakrishnan, B.A. Helmink, C.N. Spencer, A. Reuben, J.A. Wargo, Cancer Cell 33, 570-580 (2018)
53. C. Pan, Q. Guo, N. Lu, Evid. Based Complement. Alternat. Med. 2019, 2682748 (2019)
54. Y. Yang, M. Sun, W. Yao, F. Wang, X. Li, W. Wang, J. Li, Z. Gao, L. Qiu, R. You, C. Yang, Q. Ba, H. Wang, J. Immunother. Cancer 8, e000317 (2020)
55. H. Hao, Q. Zhang, H. Zhu, Y. Wen, D. Qiu, J. Xiong, X. Fu, Y. Wu, K. Meng, J. Li, Eur. J. Immunol. 49, 2235-2244 (2019)
56. W. Lam, S. Bussom, F. Guan, Z. Jiang, W. Zhang, E.A. Gullen, S.H. Liu, Y.C. Cheng, Sci. Transl. Med. 2, 45ra59 (2010)

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