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Three New Compounds from the Actinomycete Actinocorallia aurantiaca |
| Kai-Yue Han1, Xing Wu1, Chenglin Jiang2, Rong Huang1, Zheng-Hui Li1, Tao Feng1, He-Ping Chen1, Ji-Kai Liu1 |
1 School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China;
2 State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Institute of Microbiology, School of Life Sciences, Yunnan University, Kunming 650091, People's Republic of China |
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Abstract Aurantiadioic acids A (1) and B (2), two new furan-containing polyketides, and aurantoic acid A (3), a new natural product, were isolated from the liquid fermentation of the sika deer dung-derived actinomycete Actinocorallia aurantiaca. The structures of the new compounds were established by extensive spectroscopic methods, including 1D & 2D NMR, HRESIMS spectroscopic analysis. The absolute configuration of 3 was assigned by comparison of the specific optical rotations with the reported derivatives. Biological activity evaluations suggested that compounds 1-3 showed weak inhibition on NO production in the murine monocytic RAW 264.7 macrophages with IC50 values of 35.8, 41.8, 45.2 μM, respectively. Compound 3 showed weak inhibition on influenza A virus (A/PuertoRico/8/1934, H1N1) with an EC50 value of 35.9 μM, and a selective index higher than 13.3.
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| Keywords
Actinomycete
Actinocorallia aurantiaca
Polyketides
Anti-NO activity
Antiviral activity
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| Fund:This work was financially supported by National Natural Science Foundation of China (Grant No. 81773590). The authors thank Analytical & Measuring Centre, South-Central University for Nationalities, for the NMR measurements. |
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Corresponding Authors:
He-Ping Chen, Ji-Kai Liu
E-mail: chenhp@mail.scuec.edu.cn;jkliu@mail.kib.ac.cn
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Issue Date: 30 October 2019
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