Inhibitory Effect of Alpha-Mangostin to Dengue Virus Replication and Cytokines Expression in Human Peripheral Blood Mononuclear Cells

doi:10.1007/s13659-019-00218-z

Natural Products and Bioprospecting

2019, Vol. 9

Issue (5) : 345-349 DOI: 10.1007/s13659-019-00218-z

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Inhibitory Effect of Alpha-Mangostin to Dengue Virus Replication and Cytokines Expression in Human Peripheral Blood Mononuclear Cells

Zaenal Sugiyanto^1,2, Benediktus Yohan³, Soeharyo Hadisaputro^2,4, Edi Dharmana^2,4, Catharina Suharti^2,4, Winarto^2,4, Kis Djamiatun⁴, Fifin L. Rahmi⁴, R. Tedjo Sasmono³

1 Faculty of Health Science, Dian Nuswantoro University, Jl. Imam Bonjol 270, Semarang 50131, Indonesia;
2 Doctoral Program in Medical and Health Sciences, Faculty of Medicine, Diponegoro University, Jl. Prof. Sudarto SH, Tembalang, Semarang 50275, Indonesia;
3 Eijkman Institute for Molecular Biology, Ministry of Research, Technology and Higher Education, Jl. Diponegoro 69, Jakarta 10430, Indonesia;
4 Faculty of Medicine, Diponegoro University, Jl. Prof. Sudarto SH, Tembalang, Semarang 50275, Indonesia

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Abstract Massive pro-inflammatory cytokines production has been correlated with the pathogenesis of severe dengue disease. The active compound of mangosteen fruit pericarps, α-mangostin, has been commonly used as traditional medicine and dietary supplement. We examined the effect of α-mangostin against dengue virus (DENV) infection in human peripheral blood mononuclear cells (PBMC) by the measurement of virus titer and TNF-α and IFN-γ cytokines concentration post infection. Increasing concentration of α-mangostin inhibited virus replication and reduced inflammatory cytokines expression at 24- and 48-h post infection. Our results support the potential use of α-mangostin as anti-antiviral and anti-inflammatory therapies in the treatment of dengue.

Keywords Dengue Antiviral Mangostin Cytokine PBMC

Fund:We would like to thank the donor involved in this study. Financial and managerial supports from Dian Nuswantoro University are greatly acknowledged.

Corresponding Authors: R. Tedjo Sasmono E-mail: sasmono@eijkman.go.id

Issue Date: 30 October 2019

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	Zaenal Sugiyanto
	Benediktus Yohan
	Soeharyo Hadisaputro
	Edi Dharmana
	Catharina Suharti
	Winarto
	Kis Djamiatun
	Fifin L. Rahmi
	R. Tedjo Sasmono

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Zaenal Sugiyanto,Benediktus Yohan,Soeharyo Hadisaputro, et al. Inhibitory Effect of Alpha-Mangostin to Dengue Virus Replication and Cytokines Expression in Human Peripheral Blood Mononuclear Cells[J]. Natural Products and Bioprospecting, 2019, 9(5): 345-349.

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http://npb.kib.ac.cn/EN/10.1007/s13659-019-00218-z OR http://npb.kib.ac.cn/EN/Y2019/V9/I5/345

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