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Construction of Spirooxindole Skeleton Through Intramolecular Dieckmann Cyclization |
| Ting Wu1, Zhiqiang Pan2, Chengfeng Xia2 |
1. The Key Laboratory of Chemistry for Natural Products of Guizhou Province, Chinese Academy of Sciences, Guiyang 55002, China;
2. Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China |
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Abstract A highly efficient and direct approach was developed to construct the structurally diverse spirooxindole skeleton, which is an important basic motif in natural products. Both the 3,3'-pyrrolidonyl spirooxindoles and spiroindolin-2-one δ-lactones were smoothly obtained by the intramolecular Dieckmann cyclization of oxindoles in excellent yield under mild conditions.
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| Keywords
Dieckmann reaction
Cyclization
Spirooxindole
Indole
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| Fund:This work was financially supported by the Natural Science Foundation of Yunnan Province (2014FA008 and 2015FB167),and the Program for Changjiang Scholars and Innovative Research Team in University (IRT13095). |
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Issue Date: 06 February 2018
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