Sugar Derivatives of Morphine: A New Window for the Development of Potent Anesthetic Drugs

doi:10.1007/s13659-015-0060-8

Natural Products and Bioprospecting

2015, Vol. 5

Issue (3) : 111-127 DOI: 10.1007/s13659-015-0060-8

Review

Sugar Derivatives of Morphine: A New Window for the Development of Potent Anesthetic Drugs

Shyamal K. Jash¹, Dilip Gorai²

1. Department of Chemistry, Saldiha College(Affiliated to the University of Burdwan), Saldiha, Bankura 722 173, West Bengal, India;
2. Department of Chemistry, Kulti College(Affiliated to the University of Burdwan), Kulti, Burdwan 713 343, West Bengal, India

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Abstract This review provides a short account of carbohydrate derivatives of an important natural drug, morphine, along with their comparative efficacies as anesthetic agent. Sugar derivatives are found to have more prospect as anesthetic drug than morphine itself owing to their enhanced bioavailability. Synthetic schemes of these sugar derivatives and information on related patents are also included in this manuscript.

Keywords Morphine Morphine glycosides Synthesis Bioavailability Anesthetic agents Related patents

Issue Date: 11 February 2018

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Shyamal K. Jash,Dilip Gorai. Sugar Derivatives of Morphine: A New Window for the Development of Potent Anesthetic Drugs[J]. Natural Products and Bioprospecting, 2015, 5(3): 111-127.

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http://npb.kib.ac.cn/EN/10.1007/s13659-015-0060-8 OR http://npb.kib.ac.cn/EN/Y2015/V5/I3/111

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