Oxidative dearomatic approach towards the synthesis of erythrina skeleton: a formal synthesis of demethoxyerythratidinone

doi:10.1007/s13659-011-0045-1

Natural Products and Bioprospecting

2011, Vol. 1

Issue (3) : 129-133 DOI: 10.1007/s13659-011-0045-1

Regular Article

Oxidative dearomatic approach towards the synthesis of erythrina skeleton: a formal synthesis of demethoxyerythratidinone

Zhi-Qiang PAN, Ji-Xuan LIANG, Jing-Bo CHEN, Xiao-Dong YANG, Hong-Bin ZHANG

Key Laboratory of Medicinal Chemistry for Natural Resource(Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, Yunnan, China

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Abstract A concise synthetic route leading to highly functional erythrina alkaloid skeletons has been developed. The key process is an oxidative carbon-carbon coupling followed by a conjugated addition. Based on this new strategy, a formal synthesis of demethoxyerythratidinone was completed in only 6 steps from 4-aminophenol.

Keywords erythrina alkaloid oxidative dearomation demethoxyerythratidinone formal synthesis

Fund:This work was supported by grants(20925205, 21062026, 2010GA014 and 2009CB522300) from National Natural Science Foundation of China, Yunnan Province and National Basic Research Program of China(973 Program).

Issue Date: 11 February 2018

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	Hong-Bin ZHANG

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Zhi-Qiang PAN,Ji-Xuan LIANG,Jing-Bo CHEN, et al. Oxidative dearomatic approach towards the synthesis of erythrina skeleton: a formal synthesis of demethoxyerythratidinone[J]. Natural Products and Bioprospecting, 2011, 1(3): 129-133.

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http://npb.kib.ac.cn/EN/10.1007/s13659-011-0045-1 OR http://npb.kib.ac.cn/EN/Y2011/V1/I3/129

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