| Original article |
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New Taxane Diterpenoids from Taxus yunnanensis |
| Ping Hai1, Shi-Zhen Wen1, Yan Li2, Yuan Gao1,2, Xian-Jun Jiang1, Fei Wang1,2 |
1. BioBioPha Co., Ltd., Kunming 650201, China;
2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China |
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Abstract Three hitherto unknown taxane diterpenoids, namely baccatin VIII(1), baccatin IX(2), and baccatin X(3), along with 10 known analogues were isolated from an ethanolic extract of the twigs and leaves of Taxus yunnanensis. The new structures were characterized based on extensive spectroscopic analysis. Compounds 1 and 2 were tested for their in vitro cytotoxicity against five human tumor cell lines, and 1 exhibited inhibitory effects on HL-60 and MCF-7, with IC50 values of 3.44 and 9.67 μM, respectively.
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| Keywords
Taxus yunnanensis
Taxane
Baccatin
Cytotoxicity
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| Fund:This work was financially supported by the "Large-scale Compound Library" project of National Development and Reform Commission of China and the "Western Light" talents training program of Chinese Academy of Sciences. |
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Issue Date: 11 February 2018
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