New amide alkaloids from <i>Piper longum</i> fruits

doi:10.1007/s13659-013-0073-0

Natural Products and Bioprospecting

2013, Vol. 3

Issue (6) : 277-281 DOI: 10.1007/s13659-013-0073-0

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New amide alkaloids from Piper longum fruits

Jun YANG^a, Yao SU^a,b, Ji-Feng LUO^a, Wei GU^a, Hong-Mei NIU^a, Yan LI^c, Yue-Hu WANG^a, Chun-Lin LONG^a,d

a Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b College of Resources and Environmental Sciences, Hebei Agricultural University, Hebei 071000, China;
c State Key Laboratory of Phytochemisty and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
d College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China

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Abstract Three new amide alkaloids piperlongumamides A-C (1-3), together with 12 known ones (4-15), were isolated from the fruits of Piper longum. The structures of the new isolates were determined using spectroscopic data analyses. Cytotoxic activity of these amides against HL-60 (human leukemia), A-549 (human lung cancer), MCF-7 (human breast cancer), SMMC-7721 (human liver cancer) and SW480 (human rectal cancer) cell lines were evaluated. Piperchabamide B (11) exhibited weak inhibitory activity against HL-60 (IC₅₀=21.32 μM), A-549 (IC₅₀=23.82 μM) and MCF-7 (IC₅₀=16.58 μM) cell lines.

Keywords Piperaceae Piper longum amide alkaloids piperlongumamides piperchabamide B cytotoxicity

Fund:This work was funded by the Natural Science Foundation of Yunnan Province, China (No. 2011FZ205), the National Natural Science Foundation of China (Nos. 31070288, 31161140345), the Ministry of Education of China through its 111 and 985 projects (Nos. B08044, MUC98506-01000101 & MUC985-9), and the Japan Society for the Promotion of Science (No. JSPS/AP/109080).

Issue Date: 11 February 2018

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	Jun YANG
	Yao SU
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	Wei GU
	Hong-Mei NIU
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	Yue-Hu WANG
	Chun-Lin LONG

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Jun YANG,Yao SU,Ji-Feng LUO, et al. New amide alkaloids from Piper longum fruits[J]. Natural Products and Bioprospecting, 2013, 3(6): 277-281.

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http://npb.kib.ac.cn/EN/10.1007/s13659-013-0073-0 OR http://npb.kib.ac.cn/EN/Y2013/V3/I6/277

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