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Triterpenoid alkaloid derivatives from Buxus rugulosa |
| Yu-Xin YANa,b, Lin ZHOUa, Yun SUNa, Jian-Chao CHENa, Jia SUa, Yan LIa, Ming-Hua QIUa,b |
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Graduate University of Chinese Academy of Sciences, Beijing 100039, China |
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Abstract Four new triterpenoid alkaloid derivatives, buxrugulines A-D(1-4), together with four known ones(5-8), were isolated from the leaves and stems of Buxus rugulosa. The structures of compounds 1-4 were elucidated by NMR and MS spectroscopic analysis. All compounds were assayed for their cytotoxicities against HL-60, SMMC-7721, A549, MCF-7, and SW480 cells lines.
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| Keywords
Buxus rugulosa
triterpenoid alkaloid derivatives
buxruguline
cytotoxicity
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| Fund:The project was financially supported by the Knowledge Innovation Program of the CAS(Grant No. KSCX2-YW-G-038, KSCX2-YW-R-194, KSCX2-EW-R-15, and KZCX2-XB2-15-03), as well as Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China(P2008-ZZ05 and P2010-ZZ14). |
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Issue Date: 24 November 2017
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