| ORIGINAL ARTICLE |
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Vibralactone derivatives isolated from co-cultures of the basidiomycetes Stereum hirsutum and Boreostereum vibrans |
| Jinjuan Wei, Zhe-Xi Li, Gao-Ke Peng, Xinyang Li, He-Ping Chen, Ji-Kai Liu |
| School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, 430074, China |
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Abstract The basidiomycetes Stereum hirsutum and Boreostereum vibrans are two fungi of the same genus. In this study, chemical investigation on the co-cultures of the two congeneric fungi led to the isolation of eleven new vibralactone derivatives, hirsutavibrins A-K (1-11). The structures of 1-11 were elucidated by extensive NMR and HRESIMS spectroscopic analysis, and computational methods. Hirsutavibrins A (1) and B (2) showed weak cytotoxicity against the human lung cancer cell line A549. Hirsutavibrin D (4) showed moderate anti-nitric oxide activity in murine monocytic RAW 264.7 macrophages. This work not only expands the members of vibralactone derivatives with variable configurations but also opens a new avenue for fungal co-culturing study between congeneric fungi.
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| Keywords
Stereum hirsutum
Boreostereum vibrans
Basidiomycetes
Co-culture
Vibralactone derivatives
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| Fund:This work was financially supported by the National Natural Science Foundation of China (Grant number 82473810) and the Fundamental Research Funds for the Central Universities, South-Central Minzu University (Grant No. CPT22033). The authors thank the Analytical & Measuring Center, School of Pharmaceutical Sciences, South-Central Minzu University for the spectra test, and the Bioactivity Screening Center of Natural Products, Kunming Institute of Botany, CAS for biological activity screening. |
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Corresponding Authors:
He-Ping Chen, E-mail:chenhp@mail.scuec.edu.cn;Ji-Kai Liu, E-mail:liujikai@mail.scuec.edu.cn
E-mail: chenhp@mail.scuec.edu.cn;liujikai@mail.scuec.edu.cn
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Issue Date: 17 May 2025
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