| 2023-6-25 |
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The medicinal chemistry of Urtica dioica L.: from preliminary evidence to clinical studies supporting its neuroprotective activity |
| Prabhakar Semwal1, Abdur Rauf2, Ahmed Olatunde3, Pooja Singh1, Mohamed Y. Zaky4,5, Md. Mozahidul Islam6, Anees Ahmed Khalil7, Abdullah S. M. Aljohani8, Waleed Al Abdulmonem9, Giovanni Ribaudo10 |
1. Department of Biotechnology, Graphic Era Deemed to be University, 566/6 Bell Road, Clement Town, Dehra Dun, India;
2. Department of Chemistry, University of Swabi, Swabi, Pakistan;
3. Department of Medical Biochemistry, Abubakar Tafawa Balewa University, Bauchi, Nigeria;
4. Molecular Physiology Division, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt;
5. Oncology Division, Department of Biomedical and Clinical Science, Faculty of Medicine, Linköping University, Linköping, Sweden;
6. Department of Environmental Management, SESM, Independent University, Bangladesh, Bashundhara R/A, Dhaka, Bangladesh;
7. University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan;
8. Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, Qassim University, Buraydah, Saudi Arabia;
9. Department of Pathology, College of Medicine, Qassim University, Buraydah, Saudi Arabia;
10. Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy |
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Abstract Urtica dioica is a perennial herb from the family of Urticaceae that is commonly known as stinging nettle. This plant is widespread in Europe, Africa, America, and a part of Asia, as it adapts to different environments and climatic conditions. The leaves, stalk, and bark of U. dioica found applications in the field of nutrition, cosmetics, textile, pest control and pharmacology. In this connection, bioactive chemical constituents such as flavonoids, phenolic acids, amino acids, carotenoids, and fatty acids have been isolated from the plant. With this review, we aim at providing an updated and comprehensive overview of the contributions in literature reporting computational, in vitro, pre-clinical and clinical data supporting the therapeutic applications of U. dioica. Experimental evidence shows that U. dioica constituents and extracts can provide neuroprotective effects by acting through a combination of different molecular mechanisms, that are discussed in the review. These findings could lay the basis for the identification and design of more effective tools against neurodegenerative diseases.
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| Keywords
Urtica dioica
Neuroprotection
Natural compounds
Flavonoids
Medicinal chemistry
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Corresponding Authors:
Prabhakar Semwal,E-mail:semwal.prabhakar@gmail.com;Abdur Rauf,E-mail:abdurrauf@uoswabi.edu.pk;Giovanni Ribaudo,E-mail:giovanni.ribaudo@unibs.it
E-mail: semwal.prabhakar@gmail.com;abdurrauf@uoswabi.edu.pk;giovanni.ribaudo@unibs.it
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Issue Date: 18 July 2023
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