| ORIGINAL ARTICLE |
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Tetra-, penta-, and hexa-nor-lanostane triterpenes from the medicinal fungus Ganoderma australe |
| Lin Zhou, Subiy Akbar, Meng-Xi Wang, He-Ping Chen, Ji-Kai Liu |
| School of Pharmaceutical Sciences, South-Central Minzu University, 430074 Wuhan, China |
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Abstract Chemical investigation on the medicinal fungus Ganoderma australe led to the identification of ten new nor-lanostane triterpenes, namely two hexa-nor ones, ganoaustratetraenones A (1) and B (2), five penta-nor ones, ganoaustraldehydes A–E (3–7), and three tetra-nor ones ganoaustrenoic acids A–C (8–10). The chemical structures along with the absolute configurations were determined by extensive spectroscopic analysis of 1D & 2D NMR and HRESIMS data. The postulated biosynthesis pathways of these compounds were proposed. Ganoaustraldehydes A (3) and B (4) showed moderate inhibition against nitric oxide production in RAW264.7 macrophage cells with the respective IC50 values of 32.5, 34.2 μM (the IC50 of positive control pyrrolidine dithiocarbamate was 20.0 μM).
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| Keywords
Basidiomycete
Ganoderma australe
Nor-lanostane
Structural determination
Anti-NO production
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| Fund:The authors thank the National Natural Science Foundation of China (grant numbers 21961142008,22177138) for fundings. |
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Corresponding Authors:
He-Ping Chen,E-mail:chenhp@mail.scuec.edu.cn;Ji-Kai Liu,E-mail:liujikai@mail.scuec.edu.cn
E-mail: chenhp@mail.scuec.edu.cn;liujikai@mail.scuec.edu.cn
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Issue Date: 12 October 2022
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