| ORIGINAL ARTICLE |
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Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculata |
| Shui-Mei Zhang1,2, Kun Hu1, Xiao-Nian Li1, Han-Dong Sun1, Pema-Tenzin Puno1 |
1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing, 10039, People's Republic of China |
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Abstract A pair of new tetrahydrofuran lignan enantiomers, (±)-schibiculatin A [(±)-1], a new enedione lignan, schibiculatin B (2), two new cadinane-type sesquiterpenoids, schibiculatins C (3) and D (4), along with two known seco-cadinane-type sesquiterpenoids (5 and 6) and seven known miscellaneous lignans (7–13) were isolated from the stems of Schisandra bicolor var. tuberculata. The structures of 1–4 were elucidated by comprehensive analysis of their spectroscopic data, quantum chemical calculations, as well as single-crystal X-ray diffraction. A few isolated compounds were tested for their protective activities against corticosterone-induced apoptosis in PC12 cells. Among them, compounds 5 and 6 showed moderate activities.
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| Keywords
Schisandra bicolor var. tuberculata
Cadinane-type sesquiterpenoids
Lignans
Quantum chemical calculation
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| Fund:We thank Service Center for Bioactivity Screening, State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany for bioactivity screening. This project was supported financially by the National Natural Science Foundation of China (No. 81903520). |
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Corresponding Authors:
Kun Hu,E-mail:hukun@mail.kib.ac.cn;Pema-Tenzin Puno,E-mail:punopematenzin@mail.kib.ac.cn
E-mail: hukun@mail.kib.ac.cn;punopematenzin@mail.kib.ac.cn
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Issue Date: 24 June 2022
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