Structurally Diverse Sesquiterpenoids with Anti-neuroinflammatory Activity from the Endolichenic Fungus <i>Cryptomarasmius aucubae</i>

doi:10.1007/s13659-021-00299-9

Natural Products and Bioprospecting

2021, Vol. 11

Issue (3) : 325-332 DOI: 10.1007/s13659-021-00299-9

ORIGINAL ARTICLES

Structurally Diverse Sesquiterpenoids with Anti-neuroinflammatory Activity from the Endolichenic Fungus Cryptomarasmius aucubae

Yi-Jie Zhai, Jian-Nan Li, Yu-Qi Gao, Lin-Lin Gao, Da-Cheng Wang, Wen-Bo Han, Jin-Ming Gao

Shaanxi Key Laboratory of Natural Products and Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, People's Republic of China

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Abstract Two new sterpurane sesquiterpenoids named sterpurol D (1) and sterpurol E (2), and one skeletally new sesquiterpene, cryptomaraone (3), bearing a 5,6-fused bicyclic ring system, along with five known ones, sterpurol A (4), sterpurol B (5), paneolilludinic Acid (6), murolane-2α, 9β-diol-3-ene (7) and (-)-10,11-dihydroxyfarnesol (8) were isolated from an endolichenic fungus Cryptomarasmius aucubae. The structures of the new compounds were elucidated by analysis of NMR spectroscopic spectra and HRESIMS data. The absolute configurations of 1 and 2 were established by spectroscopic data analysis and comparison of specific optical rotation, as well as the biosynthetic consideration. Additionally, compounds 1, 2, 4-6, and 8 showed significant nitric oxide (NO) production inhibition in Lipopolysaccharide (LPS)-induced BV-2 microglial cells with the IC 50 values ranging from 9.06 to 14.81 μM.

Keywords Endolichenic fungus Cryptomarasmius aucubae Sesquiterpenes Anti-neuroinflammatory activity

Fund:This work was financed by the National Natural Science Foundation of China (Grant Nos. 21702169, 22077102).

Corresponding Authors: Wen-Bo Han, Jin-Ming Gao E-mail: wbhan@nwafu.edu.cn;jinminggao@nwsuaf.edu.cn

Issue Date: 04 June 2021

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Yi-Jie Zhai,Jian-Nan Li,Yu-Qi Gao, et al. Structurally Diverse Sesquiterpenoids with Anti-neuroinflammatory Activity from the Endolichenic Fungus Cryptomarasmius aucubae[J]. Natural Products and Bioprospecting, 2021, 11(3): 325-332.

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http://npb.kib.ac.cn/EN/10.1007/s13659-021-00299-9 OR http://npb.kib.ac.cn/EN/Y2021/V11/I3/325

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