Limonoids and triterpenoids from the twigs and leaves of <i>Dysoxylum hainanense</i>

doi:10.1007/s13659-011-0030-8

Natural Products and Bioprospecting

2012, Vol. 2

Issue (1) : 29-34 DOI: 10.1007/s13659-011-0030-8

Regular Article

Limonoids and triterpenoids from the twigs and leaves of Dysoxylum hainanense

Wen-Xing LIU^a,b, Gui-Hua TANG^a,b, Hong-Ping HE^a, Yu ZHANG^a, Shun-Lin LI^a, Xiao-Jiang HAO^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
b Graduate University of Chinese Academy of Sciences, Beijing 100049, China

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Abstract Four new limonoids, dysohainanins A-D(1-4), and two new triterpenoids, dysohainanins E and F(5 and 6), together with seven known ones were isolated from the twigs and leaves of Dysoxylum hainanense Merr. The structures of the new compounds were determined by a variety of spectroscopic methods. The cytotoxic activities of these compounds were evaluated, and the known compound ent-19-nor-4, 16, 18-trihydroxy-8(14)-pomaren-15-one(13) showed in vitro cytotoxicity against HL-60, A-549, MCF-7, and SW480 cells, with IC₅₀ values of 24.3, 28.1, 30.7, and 22.5 μM, respectively. Compounds 2 and 3 were tested their insecticidal activities using brine shrimp and both of them were inactive.

Keywords Dysoxylum hainanense Meliaceae limonoids triterpenoids cytotoxicity

Fund:This work was supported by grants from the Ministry of Science and Technology(2009CB522300 and 2009CB940900).

Issue Date: 11 February 2018

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Wen-Xing LIU,Gui-Hua TANG,Hong-Ping HE, et al. Limonoids and triterpenoids from the twigs and leaves of Dysoxylum hainanense[J]. Natural Products and Bioprospecting, 2012, 2(1): 29-34.

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http://npb.kib.ac.cn/EN/10.1007/s13659-011-0030-8 OR http://npb.kib.ac.cn/EN/Y2012/V2/I1/29

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