Two New Quinazoline Derivatives from the Moss Endophytic Fungus <i>Aspergillus</i> sp. and Their Anti-inflammatory Activity

doi:10.1007/s13659-020-00287-5

Natural Products and Bioprospecting

2021, Vol. 11

Issue (1) : 105-110 DOI: 10.1007/s13659-020-00287-5

ORIGINAL ARTICLES

Two New Quinazoline Derivatives from the Moss Endophytic Fungus Aspergillus sp. and Their Anti-inflammatory Activity

Ning-Ning Wang, Chun-Yu Liu, Tian Wang, Yue-Lan Li, Ke Xu, Hong-Xiang Lou

Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China

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Abstract Two new quinazoline derivatives versicomides E (1) and F (2), and 10 known compounds (3-12) were isolated from the moss endophytic fungus Aspergillus sp. Their structures were determined on the basis of extensive spectroscopic data analysis and ECD calculations. Among them, the compound 7 (6-hydroxy-3-methoxyviridicatin) was first reported as a natural product. Inhibition on LPS-induced NO production in RAW 264.7 murine macrophages found that compounds 5, 7 and 8 showed significant inhibitory effects on NO production, with IC₅₀ values of 49.85, 22.14 and 46.02 μM respectively.

Keywords Endophytic fungus Quinazoline Anti-inflammatory activity

Fund:The authors gratefully acknowledge the National Natural Science Foundation of China (Nos. 81874293 and 81630093) for financial support and Major Basic Research Program of Shandong Province (ZR2019ZD26).

Corresponding Authors: Hong-Xiang Lou E-mail: louhongxiang@sdu.edu.cn

Issue Date: 11 March 2021

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Ning-Ning Wang,Chun-Yu Liu,Tian Wang, et al. Two New Quinazoline Derivatives from the Moss Endophytic Fungus Aspergillus sp. and Their Anti-inflammatory Activity[J]. Natural Products and Bioprospecting, 2021, 11(1): 105-110.

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http://npb.kib.ac.cn/EN/10.1007/s13659-020-00287-5 OR http://npb.kib.ac.cn/EN/Y2021/V11/I1/105

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