Monoterpenoid Indole Alkaloids from Inadequately Dried Leaves of <i>Alstonia scholaris</i>

doi:10.1007/s13659-015-0066-2

Natural Products and Bioprospecting

2015, Vol. 5

Issue (4) : 185-193 DOI: 10.1007/s13659-015-0066-2

Original article

Monoterpenoid Indole Alkaloids from Inadequately Dried Leaves of Alstonia scholaris

Xu-Jie Qin^1,2, Yun-Li Zhao¹, Chang-Wei Song¹, Bei Wang^1,2, Ying-Ying Chen^1,2, Lu Liu^1,2, Qiong Li^1,2, Dan Li^1,2, Ya-Ping Liu¹, Xiao-Dong Luo¹

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China

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Abstract Six new indole alkaloids, named alstoniascholarines L-Q(1-6), together with nineteen known analogues were isolated from the inadequately dried leaves of Alstonia scholaris. Their structures were elucidated on the basis of extensive analysis of spectroscopic data and by comparison of their physical and spectroscopic data with the literature values. In addition, the new alkaloids were tested for their cytotoxic and neurite outgrowth-promoting activities.

Keywords Alstonia scholaris Inadequately dried leaves Indole alkaloids Alstoniascholarine Bioactivities

Fund:The authors are grateful to the Natural Science Foundation of China(81225024), Collaborative Innovation Center of Southwest EthnicMedicine(Guangxi Normal University), (CICSEM 2013-A), the Ministry of Science and Technology of the People's Republic of China(2014ZX09301307-003), and the Chinese Academy of Sciences(KSZD-EW-Z-004-03) for partial financial support.

Issue Date: 11 February 2018

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	Xu-Jie Qin
	Yun-Li Zhao
	Chang-Wei Song
	Bei Wang
	Ying-Ying Chen
	Lu Liu
	Qiong Li
	Dan Li
	Ya-Ping Liu
	Xiao-Dong Luo

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Xu-Jie Qin,Yun-Li Zhao,Chang-Wei Song, et al. Monoterpenoid Indole Alkaloids from Inadequately Dried Leaves of Alstonia scholaris[J]. Natural Products and Bioprospecting, 2015, 5(4): 185-193.

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http://npb.kib.ac.cn/EN/10.1007/s13659-015-0066-2 OR http://npb.kib.ac.cn/EN/Y2015/V5/I4/185

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