| Original article |
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Treatment of Iron-Loaded Veterinary Sarcoma by Artemisia annua |
| Elmar Breuer1, Thomas Efferth2 |
1. Veterinary Clinic for Pets, Müllheim/Baden, Germany;
2. Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany |
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Abstract Artemisinin, a constituent of Artemisia annua L. , is a well-known antimalarial drug. Artemisinin-type drugs also inhibit cancer growth in vitro and in vivo. Herbal extracts of A. annua inhibit the growth of cancer cell lines. Here, we report on the use of capsules containing powder of Herba Artemisiae annuae to treat pet sarcoma. The surgical tumor removal as standard treatment was supplemented by adjuvant therapy with A. annua. One cat and one dog with fibrosarcoma survived 40 and 37 months, respectively, without tumor relapse. Two other dogs suffering from fibrosarcoma and hemangioendothelial sarcoma also showed complete remission and are still alive after 39 and 26 months, respectively. A. annua was well tolerated without noticeable side effects. These four cases indicate that A. annua may be a promising herbal drug for cancer therapy.
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| Keywords
Artemisinin
Asteraceae
Scopoletin
Veterinary cancer
Comparative oncology
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| Fund:The technical assistance of Mrs. Doris Rohr and the secretarial assistance of Mrs. Ilona Zirbs are gratefully acknowledged. We are indebted to Karen Duffy(Cornell University, Ithaca, NY, USA) for critically reading the manuscript. |
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Issue Date: 11 February 2018
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1. D.L. Klayman, Science 228, 1049-1055 (1985)
2. T. Efferth, Planta Med. 73, 299-309 (2007)
3. W.S. Sun, J.X. Han, W.Y. Yang, D.A. Deng, X.F. Yue, Acta Pharmacol. Sin. 13, 541-543 (1992)
4. H.J. Woerdenbag, T.A. Moskal, N. Pras, T.M. Malingre, F.S. elFeraly, H.H. Kampinga, A.W. Konings, J. Nat. Prod. 56, 845-849 (1993)
5. G.Q. Zheng, Planta Med. 60, 54-57 (1994)
6. J.C. Moore, H. Lai, J.R. Li, R.L. Ren, J.A. McDougall, N.P. Singh, C.K. Chou, Cancer Lett. 98, 83-87 (1995)
7. T. Efferth, G. Rücker, M. Falkenberg, D. Manns, A. Olbrich, U. Fabry, R. Osieka, Arzneim. Forsch. 46, 196-200 (1996)
8. T. Efferth, H. Dunstan, A. Sauerbrey, H. Miyachi, C.R. Chitambar, Int. J. Oncol. 18, 767-773 (2001)
9. T. Efferth, Drug Resist. Updat. 8, 85-97 (2005)
10. T. Efferth, Curr. Drug Targets 7, 407-421 (2006)
11. T. Efferth, M.M. Briehl, M.E. Tome, Int. J. Oncol. 23, 1231-1235 (2003)
12. T. Efferth, F. Oesch, Biochem. Pharmacol. 68, 3-10 (2004)
13. T. Efferth, A. Benakis, M.R. Romero, M. Tomicic, R. Rauh, D. Steinbach, R. Hafer, T. Stamminger, F. Oesch, B. Kaina, M. Marschall, Free Radic. Biol. Med. 37, 998-1009 (2004)
14. G. Kelter, D. Steinbach, V.B. Konkimalla, T. Tahara, S. Taketani, H.H. Fiebig, T. Efferth, PLoS One 2, e798 (2007)
15. T. Efferth, M. Volm, In Vivo. 19, 225-232 (2005)
16. P.C. Li, E. Lam, W.P. Roos, M.Z. Zdzienicka, B. Kaina, T. Efferth, Cancer Res. 68, 4347-4351 (2008)
17. N. Berdelle, T. Nikolova, S. Quiros, T. Efferth, B. Kaina, Mol. Cancer Ther. 10, 2224-2233 (2011)
18. T. Eichhorn, S. Schloissnig, B. Hahn, A. Wendler, R. Mertens, W.D. Lehmann, R.L. Krauth-Siegel, T. Efferth, Mol. BioSyst. 8, 1311-1318 (2012)
19. T. Eichhorn, D. Winter, B. Büchele, N. Dirdjaja, M. Frank, W.D. Lehmann, R. Mertens, R.L. Krauth-Siegel, T. Simmet, J. Granzin, T. Efferth, Biochem. Pharmacol. 85, 38-45 (2013)
20. L. Steinbrück, G. Pereira, T. Efferth, Cancer Genomics Proteomics 7, 337-346 (2010)
21. T. Efferth, A. Olbrich, R. Bauer, Biochem. Pharmacol. 64, 617-623 (2002)
22. T. Efferth, A. Sauerbrey, A. Olbrich, E. Gebhart, P. Rauch, H.O. Weber, J.G. Hengstler, M.E. Halatsch, M. Volm, K.D. Tew, D.D. Ross, J.O. Funk, Mol. Pharmacol. 64, 382-394 (2003)
23. V.B. Konkimalla, M. Blunder, B. Korn, S.A. Soomro, H. Jansen, W. Chang, G.H. Posner, R. Bauer, T. Efferth, Nitric Oxide 19, 184-191 (2008)
24. V.B. Konkimalla, J.A. McCubrey, T. Efferth, Curr. Cancer Drug Targets 9, 72-80 (2009)
25. S. Sertel, T. Eichhorn, C.H. Simon, P.K. Plinkert, S.W. Johnson, T. Efferth, Molecules 15, 2886-2910 (2010)
26. B. Bachmeier, I. Fichtner, P.H. Killian, E. Kronski, U. Pfeffer, T. Efferth, PLoS One 6, e20550 (2011)
27. T. Efferth, M. Giaisi, A. Merling, P.H. Krammer, M. Li-Weber, PLoS One 2, e693 (2007)
28. M. Ramacher, V. Umansky, T. Efferth, Anticancer Drugs 20, 910-917 (2009)
29. S. Sieber, G. Gdynia, W. Roth, B. Bonavida, T. Efferth, Int. J. Oncol. 35, 149-158 (2009)
30. A. Hamacher-Brady, H.A. Stein, S. Turschner, I. Toegel, R. Mora, N. Jennewein, T. Efferth, R. Eils, N.R. Brady, J. Biol. Chem. 286, 6587-6601 (2011)
31. S. Reichert, V. Reinboldt, S. Hehlgans, T. Efferth, C. Rodel, F. Rodel, Radiother. Oncol. 103, 394-401 (2012)
32. R. Dell'Eva, U. Pfeffer, R. Vené, L. Anfosso, A. Forlani, A. Albini, T. Efferth, Biochem. Pharmacol. 68, 2359-2366 (2004)
33. L. Anfosso, T. Efferth, A. Albini, U. Pfeffer, Pharmacogenomics J. 6, 269-278 (2006)
34. S. Soomro, T. Langenberg, A. Mahringer, V.B. Konkimalla, C. Horwedel, P. Holenya, A. Brand, C. Cetin, G. Fricker, M. Dewerchin, P. Carmeliet, E.M. Conway, H. Jansen, T. Efferth, J. Cell Mol. Med. 15, 1122-1135 (2011)
35. B. Krusche, J. Arend, T. Efferth, Evid. Based Complement. Alternat. Med. 454783 (2013)
36. H.J. Zhou, J.L. Zhang, A. Li, Z. Wang, X.E. Lou, Cancer Chemother. Pharmacol. 66, 21-29 (2010)
37. N.P. Singh, H.C. Lai, J.S. Park, T.E. Gerhardt, B.J. Kim, S. Wang, T. Sasaki, Anticancer Res. 31, 4111-4114 (2011)
38. S. Noori, Z.M. Hassan, Cell. Immunol. 271, 67-72 (2011)
39. J. Hou, D. Wang, R. Zhang, H. Wang, Clin. Cancer Res. 14, 5519-5530 (2008)
40. T. Chen, M. Li, R. Zhang, H. Wang, J. Cell Mol. Med. 13, 1358-1370 (2009)
41. H. Chen, B. Sun, S. Pan, H. Jiang, X. Sun, Anticancer Drugs 20, 131-140 (2009)
42. J.H. Du, H.D. Zhang, Z.J. Ma, K.M. Ji, Cancer Chemother. Pharmacol. 65, 895-902 (2010)
43. N. Gao, A. Budhraja, S. Cheng, E.H. Liu, C. Huang, J. Chen, Z. Yang, D. Chen, Z. Zhang, X. Shi, Apoptosis 16, 511-523 (2011)
44. A.S. Tin, S.N. Sundar, K.Q. Tran, A.H. Park, K.M. Poindexter, G.L. Firestone, Anticancer Drugs 23, 370-379 (2012)
45. C.Z. Zhang, H. Zhang, J. Yun, G.G. Chen, P.B. Lai, Biochem. Pharmacol. 83, 1278-1289 (2012)
46. J.L. Zhang, Z. Wang, W. Hu, S.S. Chen, X.E. Lou, H.J. Zhou, Microvasc. Res. 87, 14-24 (2013)
47. H. Sun, X. Meng, J. Han, Z. Zhang, B. Wang, X. Bai, X. Zhang, Tumour Biol. 34, 3791-3800 (2013)
48. N.P. Singh, K.B. Verma, Arch. Oncol. 10, 279-280 (2002)
49. T.G. Berger, D. Dieckmann, T. Efferth, E.S. Schultz, J.O. Funk, A. Baur, G. Schuler, Oncol. Rep. 14, 1599-1603 (2005)
50. G.R. Rutteman, S.A. Erich, J.A. Mol, B. Spee, G.C. Grinwis, L. Fleckenstein, C.A. London, T. Efferth, Anticancer Res. 33, 1819-1827 (2013)
51. Jansen FH, Adoubi I, J C KC, DE Cnodder T, Jansen N, Tschulakow A, Efferth T. Anticancer Res. 2011, 31, 4417-4422
52. M.A. Atemnkeng, B. Chimanuka, B. Dejaegher, Y.V. Heyden, J. Plaizier-Vercammen, Exp. Parasitol. 122, 344-348 (2009)
53. M.U. Eteng, A.O. Abolaji, P.E. Ebong, E.A. Brisibe, A. Dar, N. Kabir, M. Iqbal Choudhary, Phytother. Res. 27, 602-609 (2013)
54. M.S. Müller, N. Runyambo, I. Wagner, S. Borrmann, K. Dietz, L. Heide, Trans. R. Soc. Trop. Med. Hyg. 98, 318-321 (2004)
55. RITAM Artemisia annua Task Force, M. Willcox, J. Falquet, J.F. Ferreira, B. Gilbert, E. Hsu, P.M. de Magalhaes, J. PlaizierVercammen, V.P. Sharma, C.W. Wright, W. Yaode, Afr. J. Tradit. Complement. Altern. Med. 4, 121-123 (2006)
56. C.H. Blanke, G.B. Naisabha, M.B. Balema, G.M. Mbaruku, L. Heide, M.S. Müller, Trop. Doctor 38, 113-116 (2008)
57. P. Rasoanaivo, C.W. Wright, M.L. Willcox, B. Gilbert, Malaria J. 10(Suppl 1), S4 (2011)
58. F. van der Kooy, S.E. Sullivan, J. Ethnopharmacol. 150, 1-13 (2013)
59. M.S. Müller, I.B. Karhagomba, H.M. Hirt, E. Wemakor, J. Ethnopharmacol. 73, 487-493 (2000)
60. S. de Ridder, F. van der Kooy, R. Verpoorte, J. Ethnopharmacol. 120, 302-314 (2008)
61. T. Efferth, F. Herrmann, A. Tahrani, M. Wink, Phytomedicine 18, 959-969 (2011)
62. N.P. Singh, J.F. Ferreira, J.S. Park, H.C. Lai, Planta Med. 77, 1788-1793 (2011)
63. E.G. MacEwen, Cancer Metast. Rev. 9, 125-136 (1990)
64. Chinese Pharmacopeia Commission, Pharmacopoeia of the People's Republic of China 2010 (Deutscher Apotheker Verlag, Stuttgart, 2011)
65. C. Righeschi, T. Eichhorn, A. Karioti, A.R. Bilia, T. Efferth, Cancer Genomics Proteomics 9, 143-151 (2012)
66. B.A. Teicher, Mol. Cancer Ther. 5, 2435-2443 (2006)
67. G.L. Disbrow, A.C. Baege, K.A. Kierpiec, H. Yuan, J.A. Centeno, C.A. Thibodeaux, D. Hartmann, R. Schlegel, Cancer Res. 65, 10854-10861 (2005)
68. S.A. Frazier, S.M. Johns, J. Ortega, A.L. Zwingenberger, M.S. Kent, G.M. Hammond, C.O. Rodriguez Jr, M.A. Steffey, K.A. Skorupski, Vet. Comp. Oncol. 10, 33-43 (2012)
69. W.M. Adams, P.E. Miller, D.M. Vail, L.J. Forrest, E.G. MacEwen, Vet. Radiol. Ultrasound. 39, 475-481 (1998)
70. A.P. Theon, B.R. Madewell, M.F. Harb, D.L. Dungworth, J. Am. Vet. Med. Assoc. 202, 1469-1475 (1993)
71. W.M. Adams, S.J. Withrow, R. Walshaw, J.M. Turrell, S.M. Evans, M.A. Walker, I.D. Kurzman, J. Am. Vet. Med. Assoc. 191, 311-315 (1987)
72. M.E. Nadeau, B.E. Kitchell, R.L. Rooks, S.M. LaRue, Vet. Radiol. Ultrasound. 45, 362-367 (2004)
73. W.M. Adams, D.E. Bjorling, J.E. McAnulty, E.M. Green, L.J. Forrest, D.M. Vail, J. Am. Vet. Med. Assoc. 227, 936-941 (2005)
74. S.E. Lana, W.S. Dernell, M.H. Lafferty, S.J. Withrow, S.M. LaRue, Vet. Radiol. Ultrasound. 45, 577-581 (2004)
75. V. Langova, A.J. Mutsaers, B. Phillips, R. Straw, Aust. Vet. J. 82, 676-680 (2004)
76. Y.Y. Tu, M.Y. Ni, Y.R. Zhong, L.N. Li, S.L. Cui, M.Q. Zhang, X.Z. Wang, Z. Ji, X.T. Liang, Planta Med. 44, 143-145 (1982)
77. J. Han, M. Ye, X. Qiao, M. Xu, B.R. Wang, D.A. Guo, J. Pharm. Biomed. Anal. 47, 516-525 (2008)
78. T. Carbonara, R. Pascale, M.P. Argentieri, P. Papadia, F.P. Fanizzi, L. Villanova, P. Avato, J. Pharm. Biomed. Anal. 62, 79-86 (2012)
79. N.S. Radulović, P.J. Randjelović, N.M. Stojanović, P.D. Blagojević, Z.Z. Stojanović-Radić, I.R. Ilić, V.B. Djordjević, Food Chem. Toxicol. 58, 37-49 (2013)
80. X.L. Liu, L. Zhang, X.L. Fu, K. Chen, B.C. Qian, Acta Pharmacol. Sin. 22, 929-933 (2001)
81. M. Adams, T. Efferth, R. Bauer, Planta Med. 72, 862-864 (2006)
82. X. Cai, J. Yang, J. Zhou, W. Lu, C. Hu, Z. Gu, J. Huo, X. Wang, P. Cao, Bioorg. Med. Chem. 21, 84-92 (2013) |
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