Chemical constituents from the aerial parts of <i>Euphorbia sikkimensis</i> and their bioactivities

doi:10.1007/s13659-013-0006-y

Natural Products and Bioprospecting

2013, Vol. 3

Issue (3) : 112-116 DOI: 10.1007/s13659-013-0006-y

Short Communication

Chemical constituents from the aerial parts of Euphorbia sikkimensis and their bioactivities

Da-Song YANG^a,b,c, Wei-Bing PENG^d, Zi-Lei LI^a,b,c, Xue WANG^d, Jian-Guo WEI^a,b,c, Ke-Chun LIU^d, Yong-Ping YANG^a,b,c, Xiao-Li LI^a,b,c

a Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Plant Germplasm and Genomics Center, the Germplasm Bank of Wild Species, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
c Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
d Biology Institute of Shandong Academy of Sciences, Jinan 250014, China

Abstract
References
Related Articles
Metrics

Download: PDF(766 KB) HTML ()
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks

Abstract Phytochemical investigation of the aerial parts of Euphorbia sikkimensis led to the isolation of one new diterpenoids, named sikkimenoid E (1), together with thirteen other known compounds (2-14). Their structures were established by means of spectroscopic methods. Compound 2 was identified to be a trinortriterpenoid, and derived for the first time from a natural source. In this paper we reveal for the first time its comprehensive spectral data and NMR spectral assignment. Compound 4 showed antiangiogenic activity with an IC₅₀ value of 5.66 μM in a zebrafish model, and compounds 5 and 6 exhibited cytotoxicity toward A549 cell line with IC₅₀ values of 12.12 and 6.45 μM, respectively.

Keywords Euphorbia sikkimensis ingenol trinortriterpenoid tocopherol derivatives bioactivities

Fund:This work was supported by the Basic Research Project of the Ministry of Science and Technology of China (2012FY110300), MOST grant (2008BAD98B06).

Issue Date: 11 February 2018

	Service

	E-mail this article
	E-mail Alert
	RSS
	Articles by authors

	Da-Song YANG
	Wei-Bing PENG
	Zi-Lei LI
	Xue WANG
	Jian-Guo WEI
	Ke-Chun LIU
	Yong-Ping YANG
	Xiao-Li LI

Trendmd:

Cite this article:

Da-Song YANG,Wei-Bing PENG,Zi-Lei LI, et al. Chemical constituents from the aerial parts of Euphorbia sikkimensis and their bioactivities[J]. Natural Products and Bioprospecting, 2013, 3(3): 112-116.

URL:

http://npb.kib.ac.cn/EN/10.1007/s13659-013-0006-y OR http://npb.kib.ac.cn/EN/Y2013/V3/I3/112

[1]	Shi, Q. W.; Su, X. H.; Kiyota, H. Chem. Rev. 2008, 108, 4295-4327.
[2]	Fan, J. W.; Yu, L.; Ma, L. Z.; Guo, N.; Gao, Q. S.; Zhao, Q. M.; Zeng, F. L.; Ge, F.; Wang, Q. K.; Deng, X. M.; Zeng, L. Chin. Agric. Sci. Bull. 2009, 25, 1-7.
[3]	Yang, D. S.; Zhang, Y. L.; Peng, W. B.; Wang, L. Y.; Li, Z. L.; Wang, X.; Liu, K. C.; Yang, Y. P.; Li, H. L.; Li, X. L. J. Nat. Prod. 2013, 76, 265-269.
[4]	Sherman, M. M.; Borris, R. P.; Ogura, M.; Cordell, G. A.; Farnsworth, N. R. Phytochemistry 1980, 19, 1499-1501.
[5]	Miyake, Y.; Murakami, A.; Sugiyama, Y.; Isobe, M.; Koshimizu, K.; Ohigashi, H. J. Agric. Food Chem. 1999, 47, 3151-3157.
[6]	Maldonado, E.; Apan, M. T. R.; Castorena, A. L. P. Planta Med. 1998, 64, 660-661.
[7]	Zhao, J.; Zhu, H. J.; Zhou, X. J.; Yang, T. H.; Wang, Y. Y.; Su, J.; Li, Y.; Cheng, Y. X. J. Nat. Prod. 2010, 73, 865-869.
[8]	Li, Y.; Carbone, M.; Vitale, R. M.; Amodeo, P.; Castelluccio, F.; Sicilia, G.; Mollo, E.; Nappo, M.; Cimino, G.; Guo, Y. W.; Gavagnin, M. J. Nat. Prod. 2010, 73, 133-138.
[9]	Liu, R. H.; Kong, L. Y. Nat. Prod. Rev. Dev. 2005, 17, 437-439.
[10]	Sharma, M. C.; Ohira, T.; Yatagai, M. Phytochemistry 1993, 33, 721-722.
[11]	Handa, N.; Yamada, T. Tanaka, R. Phytochemistry 2010, 71, 1774-1779.
[12]	Sung, J. H.; Lee, J. O.; Son, J. K.; Park, N. S.; Kim, M. R.; Kim, J. G.; Moon, D. C. Arch. Pharm. Res. 1999, 22, 633-637.
[13]	Tan, Q. G.; Cai, X. H.; Du, Z. Z.; Luo, X. D. Helv. Chim. Acta. 2009, 92, 2762-2768.
[14]	Wang, N.; Wang, J. H.; Cheng, J.; Li, X. J. Shenyang Pharm. Univ. 2003, 20, 425-427.
[15]	Yamauchi, R.; Kato, K.; Ueno, Y. Lipids 1988, 23, 779-783.
[16]	Giner, J. L.; Berkowitz, J. D.; Andersson, T. J. Nat. Prod. 2000, 63, 267-269.
[17]	Wang, L. Y.; Wang, N. L.; Yao, X. S.; Miyata, S.; Kitanaka, S. J. Nat. Prod. 2002, 65, 1246-1251.
[18]	Urones, J. G.; Barcala, P. B.; Cuadrado, M. J. S.; Marcos, I. S. Phytochemistry 1988, 27, 207-212.
[19]	Zechmeister, K.; Brandl, F.; Hoppe, W.; Hecker, E.; Opferkuch, H. J.; Adolf, W. Tetrahedron Lett. 1970, 11, 4075-4078.
[20]	Kim, K. H.; Choi, S. U.; Kim, Y. C.; Lee, K. R. J. Nat. Prod. 2011, 74, 54-59.
[21]	Mosmann, T. J. Immunol. Methods 1983, 65, 55-63.
[22]	Murphey, R. D.; Zon, L. I. Methods 2006, 39, 255-261.

[1]	Xu-Jie Qin, Yun-Li Zhao, Chang-Wei Song, Bei Wang, Ying-Ying Chen, Lu Liu, Qiong Li, Dan Li, Ya-Ping Liu, Xiao-Dong Luo. Monoterpenoid Indole Alkaloids from Inadequately Dried Leaves of Alstonia scholaris[J]. Natural Products and Bioprospecting, 2015, 5(4): 185-193.
[2]	Muna Ali Abdalla, Josphat C. Matasyoh. Endophytes as Producers of Peptides: An Overview About the Recently Discovered Peptides from Endophytic Microbes[J]. Natural Products and Bioprospecting, 2014, 4(5): 257-270.

Viewed

Full text

Abstract

Cited

Shared

Discussed