a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; b University of Chinese Academy of Sciences, Beijing 100049, China; c Key Laboratory of Tea Biochemistry and Biotechnology of Ministry of Education & Ministry of Agriculture, Anhui Agricultural University, Hefei 230036, China
Abstract Abietane diterpenes and miltirone series have shown important activities and for medical purposes in order to achieve the total synthesis of 1-oxomiltrone 1 and miltirone 4, a versatile intermediate 6 was found. The compound 6 could be used as a precursor A-B-C rings with different oxidative degrees in selected abietane diterpenes when synthesized through high yield Suzuki reaction and subsequent cyclization, and total synthesis of 1-oxomiltirone (1) has been achieved.
Chun-Miao LI,Hui-Chun GENG,Ming-Ming LI, et al. Total synthesis of 1-oxomiltirone via Suzuki coupling[J]. Natural Products and Bioprospecting,
2013, 3(3): 117-120.
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