Natural Products and Bioprospecting    2012, Vol. 2 Issue (2) : 65-69     DOI: 10.1007/s13659-012-0012-5
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Rauvotetraphyllines A–E, new indole alkaloids from Rauvolfia tetraphylla
Yuan GAOa,b,c, Dong-Sheng ZHOUb, Ling-Mei KONGa,c, Ping HAIb, Yan LIa, Fei WANGa,b, Ji-Kai LIUa
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b BioBioPha Co., Ltd., Kunming 650201, China;
c Graduate University of Chinese Academy of Sciences, Beijing 100039, China
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Abstract  Five new indole alkaloids rauvotetraphyllines A-E(1-5), together with eight known analogues, were isolated from the aerial parts of Rauvolfia tetraphylla. The structures were established by means of spectroscopic methods.
Keywords Rauvolfia tetraphylla      indole alkaloid      rauvotetraphylline     
Fund:This work was financially supported by National Basic Research Program of China(973 Program)2009CB522300, the "West Light" program of Chinese Academy of Sciences, and Natural Product Library Program of BioBioPha.
Issue Date: 11 February 2018
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Yuan GAO,Dong-Sheng ZHOU,Ling-Mei KONG, et al. Rauvotetraphyllines A–E, new indole alkaloids from Rauvolfia tetraphylla[J]. Natural Products and Bioprospecting, 2012, 2(2): 65-69.
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http://npb.kib.ac.cn/EN/10.1007/s13659-012-0012-5     OR     http://npb.kib.ac.cn/EN/Y2012/V2/I2/65
[1] Bemis, D. L.; Capodice, J. L.; Gorroochurn, P.; Katz, A. E.; Buttyan, R. Int. J. Oncol. 2006, 29, 1065-1073.
[2] Wright, C. W.; Phillipson, J. D.; Awe, S. O.; Kirby, G. C.; Warhurst, D. C.; Quetin-Leclercq, J.; Angenot, L. Phytother. Res. 1996, 10, 361-363.
[3] Hiwada, K. Ketsuatsu 2006, 13, 325-333.
[4] Neuss, N. Indole and Biogenetically Related Alkaloids; Academic Press:New York, 1980; Chapter 17.
[5] Gao, Y.; Wang, F.; Zhou, D. S.; Li, Y.; Liu, J. K. Nat. Prod. Bioprospect. 2011, 1, 104-107.
[6] Timmins, P.; Court, W. E. Phytochemistry 1976, 15, 733-735.
[7] Kan, C.; Potier, P.; Kan, S. K.; Jokela, R.; Lounasma, M. Phytochemistry 1986, 25, 1783-1784.
[8] Arthur, H. R.; Johns, S. R.; Lamberton, J. A.; Loo, S. N. Aust. J. Chem. 1968, 21, 1399-1401.
[9] Martìnez, J. A.; Velez, H.; Santana, T. Phytochemistry 1989, 28, 961-962.
[10] Itoh, A.; Kumashiro, T.; Yamaguchi, M.; NagaKura, N.; Mizushina, Y.; Nishi, T.; Tanahashi, T. J. Nat. Prod. 2005, 68, 848-852.
[11] Sheludko, R.; Gerasimenko, I.; Kolshorn, H.; Stockigt, J. J. Nat. Prod. 2002, 65, 1006-1010.
[12] Schübel, H.; Treiber, A.; Stokigt, J. Helv. Chim. Acta 1984, 67, 2078-2081.
[13] Verpoorte, R. J. Nat. Prod. 1986, 1, 1-25.
[14] Boger, D. L.; Wysocki Jr., R. J. J. Org. Chem. 1989, 54, 714-718.
[15] Yu, J. M.; Wang, T.; Liu, X. X.; Deschamps, J.; FlippenAnderson, J.; Liao, X. B.; Cook, J. M. J. Org. Chem. 2003, 68, 7565-7581.
[16] Katoa, L.; Bragaa, R. M.; Kochb, I.; Kinoshitab, L. S. Phytochemistry 2002, 60, 315-320.
[17] Li, L.; He, H. P.; Zhou, H.; Hao, X. J. Nat. Prod. Res. Dev. 2007, 19, 235-239.
[18] Pousset, J. L.; Poisson, J.; Olivier, L.; Le Men, J.; Janot, M. M. C. R. Acad. Sci. 1965, 261, 5538.
[19] Mosmann, T. J. Immunol. Methods 1983, 65, 55-63.
[20] Reed, L. J.; Muench, H. Am. J. Hyg. 1938, 27, 493-497.
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