| ORIGINAL ARTICLES |
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Xylariaides A and B, novel cytochalasans with a unique 5/6/5/3 ring system from a soil fungus Xylaria sp. Y01 |
| Yi-Yun Yuan1, Yan Li1, Wen-Yu Lu1, Ai-Lin Liang1, Jing Li1,2,3, Wen-Xuan Wang1,3 |
1. Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410008, Hunan, People's Republic of China;
2. Department of Pharmacy, National Clinical Research Center for Geriatric Disorder, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People's Republic of China;
3. Hunan Research Center for Drug Safety Evaluation, Hunan Key Laboratory of Pharmacodynamics and Safety Evaluation of New Drugs, Hunan Prima Drug Research Center Co., Ltd, Changsha, 410331, Hunan, People's Republic of China |
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Abstract Two new cytochalasans, xylariaides A (1) and B (2), were isolated and identified from a soil fungus Xylaria sp. Y01. Their structures were unambiguously determined by extensive spectroscopic methods including high resolution electrospray ionization mass spectrometry, ultraviolet radiation, infrared spectroscopy, and 1D/2D NMR, as well as in-depth quantum chemical calculations of gauge-including atomic orbital (GIAO) 13C NMR chemical shifts, electronic circular dichroism (ECD), and spin-spin coupling constants. The unprecedented core structure with a 5/6/5/3 fused tetracyclic ring system further enriches the scaffold types of cytochalasans.
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| Keywords
Cytochalasins
Xylaria sp.
Coupling constant calculation
ECD calculation
GIAO 13C NMR calculation
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| Fund:This work was supported by National Natural Science Foundation of China (82173713), Key Research and Development Program of Hunan Province (2022SK2031), and Natural Science Foundation of Hunan Province (2024JJ8127). Project of Hunan Administration of Traditional Chinese Medicine (B2023059), Changsha Municipal Natural Science Foundation (kq2403041). |
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Issue Date: 18 June 2025
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