Two New Phenolic Constituents from the Stems of <i>Euphorbia griffithii</i>

doi:10.1007/s13659-019-00223-2

Natural Products and Bioprospecting

2019, Vol. 9

Issue (6) : 405-410 DOI: 10.1007/s13659-019-00223-2

ORIGINAL ARTICLES

Two New Phenolic Constituents from the Stems of Euphorbia griffithii

Joseph Sakah Kaunda^1,2, Ying-Jun Zhang^1,3

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China;
2 Graduate School of the Chinese Academy of Sciences, Beijing 100039, People's Republic of China;
3 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China

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Abstract Phytochemical studies on MeOH extract of stems of Euphorbia griffithii led to the isolation of one new hydrolyzable tannin dimer, corilagiffithiin (1) and one new galloyl-glucoside (2), alongside six known ones (3-8). Their structures and absolute configurations were determined by in depth spectroscopic analyses and comparison of their 1D NMR and MS data with literature reported values. Configurations of sugar moieties were determined by acidic hydrolysis and subsequent GC analysis of their corresponding trimethylsilylated L-cysteine adduct. At a concentration of 50 μM, compounds 1-3 showed no anti-inflammatory activities.

Keywords Euphorbiaceae Euphorbia griffithii Phenolic glycosides Hydrolyzable tannins

Fund:The authors appreciate the members of the analytical group at the State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, for measuring the spectroscopic data. This work was partially supported by Yunnan Key Laboratory of Natural Medicinal Chemistry (S2017-ZZ14).

Corresponding Authors: Ying-Jun Zhang E-mail: zhangyj@mail.kib.ac.cn

Issue Date: 11 December 2019

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Joseph Sakah Kaunda,Ying-Jun Zhang. Two New Phenolic Constituents from the Stems of Euphorbia griffithii[J]. Natural Products and Bioprospecting, 2019, 9(6): 405-410.

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http://npb.kib.ac.cn/EN/10.1007/s13659-019-00223-2 OR http://npb.kib.ac.cn/EN/Y2019/V9/I6/405

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