Antitumor Triterpenoid Saponin from the Fruits of <i>Avicennia marina</i>

doi:10.1007/s13659-018-0167-9

Natural Products and Bioprospecting

2018, Vol. 8

Issue (5) : 347-353 DOI: 10.1007/s13659-018-0167-9

ORIGINAL ARTICLES

Antitumor Triterpenoid Saponin from the Fruits of Avicennia marina

Xiong-Wu Yang^1,3, Zhi Dai^2,3, Bei Wang^1,3, Ya-Ping Liu^1,4, Xu-Dong Zhao², Xiao-Dong Luo^1,4

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, People's Republic of China;
3 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
4 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China

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Abstract The fruits of Avicennia marina are widely used for both medicine and food in Guangxi of China. As a part of our continuous effort to search for bioactive molecules from the plant, the fruits of A. marina were investigated, which has led to one new triterpenoid saponin (1) and 29 known compounds been isolated and their structures were established by using spectroscopic methods and comparing with literature data. The new triterpenoid saponin showed cytotoxicity against GSC-3# and GSC-18# with the IC₅₀ values were 12.21 and 5.53 μg/mL respectively, and most of the known compounds had significant antioxidant capacity with the IC₅₀ values ranging from 0.36 to 13.07 μg/mL.

Keywords Avicennia marina Triterpenoid saponin GSCs DPPH

Fund:The authors are grateful to the Natural Science Foundation of China (31770388, 81225024) and the "Ten Thousand Plan", a National High-level Talents Special Support Plan for partial financial support.

Corresponding Authors: Xu-Dong Zhao, Xiao-Dong Luo E-mail: zhaoxudong@mail.kiz.ac.cn;xdluo@mail.kib.ac.cn

Issue Date: 19 September 2018

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Xiong-Wu Yang,Zhi Dai,Bei Wang, et al. Antitumor Triterpenoid Saponin from the Fruits of Avicennia marina[J]. Natural Products and Bioprospecting, 2018, 8(5): 347-353.

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http://npb.kib.ac.cn/EN/10.1007/s13659-018-0167-9 OR http://npb.kib.ac.cn/EN/Y2018/V8/I5/347

1. S.Z. Wang, Z.L. Li, G.L. Yang, C.T. Ho, S.M. Li, Food Funct. 8, 1749-1762 (2017)
2. S. Mihara, H. Tateba, O. Nishimura, Y. Machii, K. Kishino, J. Agric. Food Chem. 35, 532-537 (1987)
3. P.F. Zhu, Z. Dai, B. Wang, X. Wei, H.F. Yu, Z.R. Yan, X.D. Zhao, Y.Y. Liu, X.D. Luo, Nat. Prod. Bioprospect. 7, 421-431 (2017)
4. X.R. Wang, C.L. Zhang, Y.J. Peng, H.M. Zhang, Z.G. Wang, Y.L.Y. Gao, H.L. Zhang, Food Chem. 246, 41-47 (2018)
5. J.M. Kong, L.S. Chia, N.K. Goh, T.F. Chia, R. Brouillard, Phytochemistry 64, 923-933 (2003)
6. R. Krikorian, M.D. Shidler, T.A. Nash, W. Kalt, M.R. VinqvistTymchuk, B. Shukitt-Hale, J.A. Joseph, J. Agric. Food Chem. 58, 3996-4000 (2010)
7. X.Q. Ning, Y.B. Lin, Y.F. Tan, Guide China Med 11, 73-75 (2013)
8. C.L. Shao, X.M. Fu, C.Y. Wang, L. Han, X. Liu, Y.C. Fang, G.Q. Li, G.X. Liu, H.S. Guan, Period. Ocean Univ. China 39, 712-718 (2009)
9. W.P. Xie, C.H. Gao, X.X. Yi, W. Yi, B.J. He, B. Chen, Guihaia 34, 398-401 (2014)
10. K. Nishimura, T. Miyase, H. Noguchi, J. Nat. Prod. 62, 1128-1133 (1999)
11. L. Wang, Y. Cai, X.Q. Zhang, Carbohydr. Res. 349, 39-43 (2012)
12. T.J. Hsich, Y.C. Wu, W.L. Lo, S.C. Chen, S.H. Kuo, C.Y. Chen, Chin. Pharm. J. 56, 17-23 (2004)
13. C.N. Xia, H.B. Li, F. Liu, W.X. Hu, Bioorg. Med. Chem. Lett. 18, 6553-6557 (2008)
14. Y.M. Chang, H.K. Liu, J.M. Lo, S.C. Chien, Y.F. Chan, T.H. Lee, J.K. Su, Y.H. Kuo, J. Chin. Chem. Soc. 50, 161-166 (2003)
15. H. Saito, M. Yokoi, M. Aida, M. Kodama, T. Oda, Y. Sato, Magn. Reson. Chem. 26, 155-161 (1988)
16. R. Lang, C. Mueller, T. Hofmann, J. Agric. Food Chem. 54, 5755-5762 (2006)
17. A. Alam, S. Tsuboi, Tetrahedron 63, 10454-10465 (2007)
18. L. Han, X.S. Huang, H.M. Dahse, U. Moellmann, H.Z. Fu, S.S. Grabley, I. Sattler, W.H. Lin, J. Nat. Prod. 70, 923-927 (2007)
19. Q.F. Zhu, Y.Y. Wang, W. Jiang, H.B. Qu, J. Asian Nat. Prod. Res. 15, 258-264 (2013)
20. O. Frank, S. Blumberg, C. Kunert, J. Agric. Food Chem. 55, 1945-1954 (2007)
21. V. Milovanovic, N. Radulovic, V. Mitic, R. Palic, G. Stojanovic, J. Essent. Oil Res. 20, 310-314 (2008)
22. A.F. Barrero, E.J. Alvarez-Manzaneda, R. Chahboun, A.R. Rivas, P.L. Palomino, Tetrahedron 56, 6099-6113 (2000)
23. T. Tanaka, T. Ikeda, M. Kaku, X.H. Zhu, M. Okawa, K. Yokomizo, M. Uyeda, T. Nohara, Chem. Pharm. Bull. 52, 1242-1245 (2004)
24. Y.J. Chen, H.G. Zhang, X. Li, Chem. Nat. Compd. 45, 330-332 (2009)
25. M.Z. Yang, X.Q. Wang, C. Li, Chin. Tradit. Herb. Drugs 17, 2447-2452 (2014)
26. T. Kanchanapoom, R. Kasai, K. Yamasaki, Phytochemistry 59, 565-570 (2002)
27. T. Shen, X.Q. Li, W.C. Hu, J. Korean Soc. Appl. Biol. Chem. 58, 617-625 (2015)
28. E.J. Lee, J.S. Kim, H.P. Kim, J.H. Lee, S.S. Kang, Food Chem. 120, 134-139 (2010)
29. Y. Sun, J. Ouyang, Z.W. Deng, Q.S. Li, W.H. Lin, Magn. Reson. Chem. 46, 638-642 (2008)
30. Y.J. Narukawa, N. Shimizu, T. Takeda, Nat. Med. 55, 79-82 (2001)
31. T. Han, H.L. Li, Q.Y. Zhang, H.C. Zheng, L.P. Qin, Chem. Nat. Compd. 42, 567-570 (2006)
32. J. Tian, Q.S. Zhao, H.J. Zhang, J. Nat. Prod. 60, 766-769 (1997)
33. X.J. Shi, J.H. Zhu, L. Yang, Chin. Med. Mat. 42, 870-873 (2011)
34. I.C. Jones, G.J. Sharman, J. Pidgeon, Magn. Reson. Chem. 43, 497-509 (2005)
35. B. Wang, Z. Dai, L. Liu, X. Wei, P. Zhu, H.F. Yu, Y.P. Liu, X.D. Luo, Nat. Prod. Bioprospect. 6, 285-290 (2016)
36. K.O. Eyong, G. Bairy, A.A. Eno, J. Taube, K.G. Hull, G.N. Folefoc, H.S. Foyet, D. Romo, Med. Chem. Res. 27, 268-277 (2018)
37. Y.F. Qu, J.Y. Gao, J. Wang, Y.M. Geng, Y. Zhou, C.X. Sun, F. Li, L. Feng, M.J. Yu, G.S. Wang, Molecules 22, 1731/1-1731/9 (2017)
38. S.M. Kazuko, F.K. Kuniko, Y.H. Keiko, N.K. Takashi, J. Agric. Food Chem. 40, 945-948 (1992)

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