Chemical constituents from the aerial parts of <i>Musella lasiocarpa</i>

doi:10.1007/s13659-011-0007-7

Natural Products and Bioprospecting

2011, Vol. 1

Issue (1) : 41-47 DOI: 10.1007/s13659-011-0007-7

Regular Article

Chemical constituents from the aerial parts of Musella lasiocarpa

Liao-Bin DONG^a,b, Juan HE^a, Xing-Yao LI^a,b, Xing-De WU^a,b, Xu DENG^a,b, Gang XU^a, Li-Yan PENG^a, Yu ZHAO^a, Yan LI^a, Xun GONG^a, Qin-Shi ZHAO^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Graduate University of Chinese Academy of Sciences, Beijing 100039, China

Abstract
References
Related Articles
Metrics

Download: PDF(722 KB) HTML ()
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks

Abstract Phytochemical investigation of the aerial parts of the monotypic plant, Musella lasiocarpa, led to the isolation of four rare bicyclic diarylheptanoids, musellarins B-E(2-5), two new phenylphenalenones, 2-methoxy-9-(3', 4'-dihydroxyphenyl)-1H-phenalen-1-one(9), 2-methoxy-9-(3'-methoxy-4'-hydroxyphenyl)-1H-phenalen-1-one(10), a new acenaphtylene derivative, trans-(1S, 2S)-3-(4'-methoxyphenyl)-acenaphthene-1, 2-diol(13), and two new sucrose esters, 1, 2', 3', 4', 6'-O-pentaacetyl-3-O-trans-p-coumaroylsucrose(16), 1, 2', 3', 4', 6'-O-pentaacetyl-3-O-cis-p-coumaroylsucrose(17), together with nine known compounds. In addition,(4E, 6E)-1-(3', 4'-dihydroxyphenyl)-7-(4"-hydroxyphenyl)-hepta-4, 6-dien-3-one(15) was isolated for the first time from a natural source. The structures of new compounds were elucidated by analysis of their spectroscopic data. Compounds 2, 6, 8-10, 12, and 14 were cytotoxic toward several of the human tumor cell lines(HL-60, SMMC-7721, A-549, MCF-7, and SW480). Of these, the new compound 9 was the most potent one, with IC₅₀ values of 5.8, 10.3, 6.3, 3.3, and 2.3 μM, respectively.

Keywords monotypic diarylheptanoid phenylphenalenone acenaphtylene sucrose ester Musella lasiocarpa

Fund:This work was financially supported by the National Basic Research Program of China(973 Program No. 2009CB522303 and No. 2011CB915503), the NSFC(No. U0932602), the National Natural Science Foundation of China(No. 90813004), and the State Key Laboratory of Phytochemistry and Plant Resources in West China(No. P2010-ZZ05).

Issue Date: 10 November 2017

	Service

	E-mail this article
	E-mail Alert
	RSS
	Articles by authors

	Liao-Bin DONG
	Juan HE
	Xing-Yao LI
	Xing-De WU
	Xu DENG
	Gang XU
	Li-Yan PENG
	Yu ZHAO
	Yan LI
	Xun GONG
	Qin-Shi ZHAO

Trendmd:

Cite this article:

Liao-Bin DONG,Juan HE,Xing-Yao LI, et al. Chemical constituents from the aerial parts of Musella lasiocarpa[J]. Natural Products and Bioprospecting, 2011, 1(1): 41-47.

URL:

http://npb.kib.ac.cn/EN/10.1007/s13659-011-0007-7 OR http://npb.kib.ac.cn/EN/Y2011/V1/I1/41

[1]	Wu, D. L.; Cai, X. T.; Li, X. W. Flora Reipublicae Popularis Sinicae; Science Press:Beijing, 1981; vol. 16(2), pp 3-6.
[2]	Liu, A. Z.; Kress, W. J.; Long, C. L. Econ. Bot. 2003, 57, 279-281.
[3]	Yang, W. L.; Tian, J.; Bai, B.; Guan, J.; Ding, L. Chin. Tradit. Herb. Drugs 2001, 32, 681-683.
[4]	Qin, B.; Shao, Z. Y; Zeng, W.; Wang, H. Q.; Zhu, D. Y. J. Chin. Chem. Soc. 2006, 53, 475-478.
[5]	Qin, B.; Lu, R. H.; Wang, H. Q.; Wang, M. Nat. Prod. Res. & Dev. 2000, 12, 41-44.
[6]	Dong, L. B.; He, J.; Wang, Y. Y.; Wu, X. D.; Deng, X.; Pan, Z. H.; Xu, G.; Peng, L. Y.; Zhao, Y.; Li, Y.; Gong, X.; Zhao, Q. S. J. Nat. Prod. 2011, 74, 234-239.
[7]	Jang, D. S.; Park, E. J.; Hawthorne, M. E.; Vigo, J. S.; Graham, J. G.; Cabieses, F.; Santarsiero, B. D.; Mesecar, A. D.; Fong, H. H. S.; Mehta, R. G.; Pezzuto, J. M.; Kinghorn, A. D. J. Agric. Food Chem. 2002, 50, 6330-6334.
[8]	Kamo, T.; Kato, N.; Hirai, N.; Tsuda, M.; Fujioka, D.; Ohigashi, H. Biosci. Biotechnol. Biochem. 1998, 62, 95-101.
[9]	Luis, J. G.; Lahlou, E. H.; Andres, L. S.; Echeverri, F.; Fletcher, W. Q. Tetrahedron 1997, 53, 8249-8256.
[10]	Sternhell, S.; Westerman, P. W. J. Org. Chem. 1974, 39, 3794-3796.
[11]	Wang, L. X.; Wang, X. Y.; Cui, J. N.; Ren, W. M.; Meng, N.; Wang, J. Y.; Qian, X. H. Tetrahedron:Asymmetry 2010, 21, 825-830.
[12]	Imuta, M.; Kasai, M.; Ziffer, H. Bioorg. Chem. 1985, 13, 131-134.
[13]	Shimazaki, N.; Mimaki, Y.; Sashida, Y. Phytochemistry 1991, 30, 1475-1480.
[14]	Sasaya, T. Enshurin Kenkyu Hokoku (Hokkaido Daigaku Nogakubu) 1985, 42, 191-205.
[15]	Cooke, R. G.; Thomas, R. L. Aust. J. Chem. 1975, 28, 1053-1057.

[1]	Jian-Qiang ZHAO, Yan-Ming WANG, Dong WANG, Chong-Ren YANG, Min XU, Ying-Jun ZHANG. Five new sucrose esters from the whole plants of Phyllanthus cochinchinensis[J]. Natural Products and Bioprospecting, 2013, 3(2): 61-65.

Viewed

Full text

Abstract

Cited

Shared

Discussed