Neolignans and Norlignans from Insect Medicine <i>Polyphaga plancyi</i> and Their Biological Activities

doi:10.1007/s13659-020-00262-0

Natural Products and Bioprospecting

2021, Vol. 11

Issue (1) : 51-62 DOI: 10.1007/s13659-020-00262-0

ORIGINAL ARTICLES

Neolignans and Norlignans from Insect Medicine Polyphaga plancyi and Their Biological Activities

Hong-Jie Zhu², Te Xu¹, Yong-Ming Yan¹, Zheng-Chao Tu^3,4, Yong-Xian Cheng¹

1 School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, People's Republic of China;
2 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
3 International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education(MOE), College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China;
4 Drug Discovery Pipeline & Guangdong Provincial Key Laboratory of Biocomputing, Guangzhou Institutes of Biomedicine and Health, Guangzhou 510530, People's Republic of China

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Abstract Ten neolignans or norlignans (1-10) including eight new compounds were isolated from the whole bodies of Polyphaga plancyi Bolivar. Their structures were identified by spectroscopic data. Compounds 3, 4, 8, and 9 are racemates indicated by chiral HPLC analysis. Chiral separation followed by ECD calculations allowed to clarify the absolute configurations of all the antipodes. All the new compounds were evaluated for their biological properties toward extracellular matrix in rat renal proximal tubular cells, human cancer cells (K562, A549, and Huh7), EV71, ROCK2, JAK3, DDR1, and coagulation.

Keywords Polyphaga plancyi Insect medicine Lignans Renal protection Anticoagulant activity

Fund:This study was supported by the National Science Fund for Distinguished Young Scholars (81525026) and Shenzhen Government’s Plan of Science and Technology (JCYJ20170412110504956).

Corresponding Authors: Yong-Xian Cheng E-mail: yxcheng@szu.edu.cn

Issue Date: 11 March 2021

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Hong-Jie Zhu,Te Xu,Yong-Ming Yan, et al. Neolignans and Norlignans from Insect Medicine Polyphaga plancyi and Their Biological Activities[J]. Natural Products and Bioprospecting, 2021, 11(1): 51-62.

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http://npb.kib.ac.cn/EN/10.1007/s13659-020-00262-0 OR http://npb.kib.ac.cn/EN/Y2021/V11/I1/51

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