Antiproliferative Triterpenoid Saponins from <i>Leptaulus citroides</i> Baill. from the Madagascar Rain Forest

doi:10.1007/s13659-015-0083-1

Natural Products and Bioprospecting

2016, Vol. 6

Issue (1) : 31-39 DOI: 10.1007/s13659-015-0083-1

Original article

Antiproliferative Triterpenoid Saponins from Leptaulus citroides Baill. from the Madagascar Rain Forest

Qingxi Su¹, Peggy J. Brodie¹, Yixi Liu¹, James S. Miller², Naina M. Andrianjafy³, Rabodo Antsiferana⁴, Vincent E. Rasamison⁵, David G. I. Kingston¹

1. Department of Chemistry, Virginia Tech Center for Drug Discovery, M/C 0212, Virginia Tech, Blacksburg VA, 24061, USA;
2. Missouri Botanical Garden, P. O. Box 299, St. Louis, MO 63166-0299, USA;
3. Missouri Botanical Garden, B. P 3391, 101 Antananarivo, Madagascar;
4. Centre National d'Application des Recherches Pharmaceutiques, B. P 702, 101 Antananarivo, Madagascar

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Abstract Bioassay-guided fractionation of EtOH extracts obtained from the roots and wood of the Madagascan plant Leptaulus citroides Baill. (Cardiopteridaceae) led to the isolation of ethyl esters of three new triterpenoid saponins (1-3) and the known sesquiterpenoid cinnamosmolide (4). The structures of 1-3 were elucidated by extensive 1D and 2D NMR experiments and mass spectrometry. Compounds 1, 2, and 4 showed moderate cytotoxicity against the A2780 human ovarian cancer cell line with IC₅₀ values of 2.8, 10.2 and 2.0 lM, respectively.

Keywords Antiproliferative activity Triterpenoid saponins Leptaulus citroides (Cardiopteridacea)

Issue Date: 08 February 2018

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	Qingxi Su
	Peggy J. Brodie
	Yixi Liu
	James S. Miller
	Naina M. Andrianjafy
	Rabodo Antsiferana
	Vincent E. Rasamison
	David G. I. Kingston

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Qingxi Su,Peggy J. Brodie,Yixi Liu, et al. Antiproliferative Triterpenoid Saponins from Leptaulus citroides Baill. from the Madagascar Rain Forest[J]. Natural Products and Bioprospecting, 2016, 6(1): 31-39.

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http://npb.kib.ac.cn/EN/10.1007/s13659-015-0083-1 OR http://npb.kib.ac.cn/EN/Y2016/V6/I1/31

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