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Phthalide mono- and dimers from the rhizomes of Angelica sinensis and their anti-inflammatory activities |
| Hongyan Wen1,2, Sheng Li2, Yu Zhang2 |
1. College of Ethnic Medicine, Yunnan University of Chinese Medicine, Kunming, 650500, China;
2. State Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China |
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Abstract Three pairs of enantiomeric phthalide dimers, including two new ones, angesicolides A (1) and B (2), and a new phthalide monomer (3), were obtained from the rhizomes of Angelica sinensis. Their structures were established through spectroscopic methods, quantum calculations, and chiral HPLC analysis. Compounds 1 and 2 were [2+2] and [4+2] cycloadducts of phthalide monomers, and their hypothetical biogenetic origin was proposed. Compounds 2, (+)-2, (-)-2, 4, (+)-4, and (-)-4 exhibited significant inhibitory activity against NO production with IC50 values range from 1.23 to 5.55 μM.
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| Keywords
Angelica sinensis
Phthalide dimers
Angesicolides A and B
Anti-inflammatory activity
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| Fund:This work was financially supported by National Key R&D Program of China (2022YFF1100301), Major Science and Technology Project of Henan Province (231100310200), Yunnan Province Science and Technology Department (202305AH340005). |
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Issue Date: 18 June 2025
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