REVIEWS |
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Natural and engineered xylosyl products from microbial source |
Jianzhao Qi1,2,3, Shi-jie Kang1, Ling Zhao2, Jin-ming Gao1, Chengwei Liu1,3 |
1 Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China; 2 Department of Pharmacy, School of Medicine, Xi'an International University, Xi'an 710077, China; 3 Key Laboratory for Enzyme and Enzyme-Like Material Engineering of Heilongjiang, College of Life Science, Northeast Forestry University, Harbin 150040, China |
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Abstract Glycosylation is a prevalent post-modification found in natural products and has a significant impact on the structural diversity and activity variation of natural products. Glucosylation is the most common type of glycosylation, whereas xylosylation is relatively rare. Despite their unique chemical structures and beneficial activities, xylosylated natural products from microorganisms have received little attention. This review provides, for the first time, a comprehensive summary of 126 microbial-derived xylosylated natural products, including xylosyl-cyathane diterpenes, xylosylated triterpenes, xylosyl aromatic compounds, and others. Among these compounds, xylosyl-cyathane diterpenes represent the highest number of derivatives, followed by xylosylated triterpenes. Xylosyl compounds from bacterial sources have less defined structural profiles compared to those from fungi. The characterization of xylosyltransferase EriJ from Basidiomycota extended the structural diversity of xylosyl cyathane diterpenes. This work provides a valuable reference for the research and use of xylosyltransferase for drug discovery and synthetic chemistry. Further work is needed to explore the potential applications of microbial derived xylosyl compounds and to develop novel xylosyl transferases. With the deepening of genomic sequencing of medicinal fungi, more biosynthesis of bioactive xylosyl compounds is expected to be elucidated in the future.
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Keywords
Xylosyl product
Cyathane diterpene
Engineering transformation
Xylosyltransferase
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Fund:This work was supported by the Key R&D Projects in Shaanxi Province of China (No. 2023-YBSF-164), the National Natural Science Foundation of China (No. 31800031 and No. 32370069), the Fundamental Research Funds for the Central Universities (2572023AW40), and the Natural Science Foundation of Heilongjiang Province of China (No. LH2023C035). |
Corresponding Authors:
Jianzhao Qi,E-mail:qjz@nwafu.edu.cn;Chengwei Liu,E-mail:liuchw@nefu.edu.cn
E-mail: qjz@nwafu.edu.cn;liuchw@nefu.edu.cn
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Issue Date: 14 June 2024
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