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Structural derivatization strategies of natural phenols by semi-synthesis and total-synthesis |
| Ding Lin1,2, Senze Jiang1,2, Ailian Zhang1,2, Tong Wu1,2, Yongchang Qian1,2, Qingsong Shao1,2 |
1 State Key Laboratory of Subtropical Silviculture, Zhejiang A & F University, Hangzhou 311300, China;
2 Zhejiang Provincial Key Laboratory of Resources Protection and Innovation of Traditional Chinese Medicine, Zhejiang A & F University, Hangzhou 311300, China |
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Abstract Structural derivatization of natural products has been a continuing and irreplaceable source of novel drug leads. Natural phenols are a broad category of natural products with wide pharmacological activity and have offered plenty of clinical drugs. However, the structural complexity and wide variety of natural phenols leads to the difficulty of structural derivatization. Skeleton analysis indicated most types of natural phenols can be structured by the combination and extension of three common fragments containing phenol, phenylpropanoid and benzoyl. Based on these fragments, the derivatization strategies of natural phenols were unified and comprehensively analyzed in this review. In addition to classical methods, advanced strategies with high selectivity, efficiency and practicality were emphasized. Total synthesis strategies of typical fragments such as stilbenes, chalcones and flavonoids were also covered and analyzed as the supplementary for supporting the diversity-oriented derivatization of natural phenols.
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| Keywords
Natural phenols
Structural derivatization
Common fragments
Total synthesis
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| Fund:This review was supported by National Training Program of Innovation and Entrepreneurship for Undergraduates (202101341012) and Talent Startup Project of Zhejiang A & F University Scientifc Research and Development Fund (2034020154). |
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Corresponding Authors:
Ding Lin, E-mail:linding@zafu.edu.cn;Qingsong Shao, E-mail:sqszjfc@126.com
E-mail: linding@zafu.edu.cn;sqszjfc@126.com
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Issue Date: 26 April 2022
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