Anti-microbial Effects In Vitro and In Vivo of <i>Alstonia scholaris</i>

doi:10.1007/s13659-020-00294-6

Natural Products and Bioprospecting

2021, Vol. 11

Issue (1) : 127-135 DOI: 10.1007/s13659-020-00294-6

ORIGINAL ARTICLES

Anti-microbial Effects In Vitro and In Vivo of Alstonia scholaris

Yun-Li Zhao^1,2, Zhong-Ping Gou³, Jian-Hua Shang², Wan-Yi Li⁴, Yu Kuang⁴, Ming-Yuan Li⁴, Xiao-Dong Luo^1,2

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education;Yunnan Provincial Center for Research & Development of Natural Products;School of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China;
3 Institute of Drug Clinical Trials, West China Hospital, Sichuan University, Chengdu 610041, China;
4 West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China

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Abstract Alstonia scholaris could be used as a traditional medicinal plant in China for the treatment of acute respiratory, which might be caused by respiratory tract infections. The investigation tested the anti-infective effects of total alkaloids extract (TA) from leaves of A. scholaris, and as a result, TA inhibited herpes simplex virus type 1 (HSV-1), respiratory syncytial virus (RSV) and influenza A virus (H1N1) in vitro respectively. In addition, the survival days of mice were prolonged, and the lung weights and mortality of mice were decreased significantly, after oral administrated TA in H1N1 and beta-hemolytic streptococcus infectious models in vivo respectively. The finding supported partly the traditional usage of A. scholaris in the treatment respiratory infections.

Keywords Alstonia scholaris Total alkaloids Acute respiratory infections Anti-virus Anti-bacteria

Fund:The authors are grateful to the general program of applied basic research of Yunnan province (2019FB116) and the National Key Research and Development Program of China (2017YFC1704007) for partly financial support.

Corresponding Authors: Ming-Yuan Li, Xiao-Dong Luo E-mail: lmy3985@sina.com;xdluo@mail.kib.ac.cn

Issue Date: 11 March 2021

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Yun-Li Zhao,Zhong-Ping Gou,Jian-Hua Shang, et al. Anti-microbial Effects In Vitro and In Vivo of Alstonia scholaris[J]. Natural Products and Bioprospecting, 2021, 11(1): 127-135.

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http://npb.kib.ac.cn/EN/10.1007/s13659-020-00294-6 OR http://npb.kib.ac.cn/EN/Y2021/V11/I1/127

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