| ORIGINAL ARTICLES |
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Pharmacokinetic Analysis of Four Bioactive Iridoid and Secoiridoid Glycoside Components of Radix Gentianae Macrophyllae and Their Synergistic Excretion by HPLC-DAD Combined with Second-Order Calibration |
| Tian-Ming Yang1, Yang-Xi Liu1, Hai-Yan Fu1, Wei Lan1, Han-Bo Su1, He-Bin Tang1, Qiao-Bo Yin1, He-Dong Li1, Li-Ping Wang1, Hai-Long Wu2 |
1 The Modernization Engineering Technology Research Center of Ethnic Minority Medicine of Hubei Province, School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China;
2 State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China |
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Abstract An HPLC-DAD method combined with second-order calibration based on the alternating trilinear decomposition (ATLD) algorithm with the aid of region selection was developed to simultaneously and quantitatively characterize the synergistic relationships and cumulative excretion of the four bioactive ingredients of Radix Gentianae Macrophyllae in vivo. Although the analytes spectra substantially overlapped with that of the biological matrix, the overlapping profiles between analytes and co-eluting interferences can be successfully separated and accurately quantified by the ATLD method on the basis of the strength of region selection. The proposed approach not only determined the content change but also revealed the synergistic relationships and the cumulative excretion in vivo of the four ingredients in urine and feces samples collected at different excretion time intervals. In addition, several statistical parameters were employed to evaluate the accuracy and precision of the method. Quantitative results were confirmed by HPLC-mass spectrometry. Satisfactory results indicated that the proposed approach can be utilized to investigate the pharmacokinetics of Radix Gentianae Macrophyllae excretion in vivo.
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| Keywords
Radix Gentianae Macrophyllae
HPLC-DAD
Second-order calibration
Pharmacokinetic analysis
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| Fund:Authors are grateful to the financial support from the National Natural Science Foundation of China (Grants Nos. 21776321, 21576297, 21205145, 21575039) and Key Projects of Technological Innovation of Hubei Province (2016ACA138). The Open Research Program (Grant Nos. 2015ZD001, 2015ZD002 and 2015ZY006) from the Modernization Engineering Technology Research Center of Ethnic Minority Medicine of Hubei province (South-Central University for Nationalities). |
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Corresponding Authors:
Hai-Yan Fu, Hai-Long Wu
E-mail: fuhaiyan@mail.scuec.edu.cn;hlwu@hnu.edu.cn
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Issue Date: 09 December 2017
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