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Identification and Cytotoxic Activities of Two New Trichothecenes and a New Cuparane-Type Sesquiterpenoid from the Cultures of the Mushroom Engleromyces goetzii |
| Yang Wang1,2, Ling Zhang1, Gen-Tao Li1, Zheng-Hui Li1, Ze-Jun Dong1, Yan Li1, Ji-Kai Liu1 |
1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2. University of Chinese Academy of Sciences, Beijing 100049, China |
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Abstract Engleromyces goetzii is a traditional medicinal mushroom that is widely used to treat infection, inflammation and cancer in Tibet, Sichuan and Yunnan provinces of China. Two new trichothecenes, engleromycones A and B(1 and 2), one new cuparane-type sesquiterpenoid named infuscol F(11), eight known trichothecene analogs, sambucinol(3), 3-deoxysambucinol(4), trichothecolone(5), trichodermol(6), 8-deoxytrichothecin(7), trichothecin(8), trichothecinol B(9) and trichothecinol A(10), and one known cyclopentanoid sesquiterpene cyclonerodiol(12) were isolated from the cultures of E. goetzii. The new compounds were elucidated through spectroscopic analyses. The anticancer effects of trichothecenes 1-10 were examined in the HL-60, SMMC-7721, A549, MCF-7, and SW-480 human cancer cell lines using an MTT assay. Trichothecinol A(10) significantly inhibited the growth of MCF-7 cells, with an IC50 value of 0.006 μM, which was comparable to the cytotoxic activity of the positive control, paclitaxel, indicating that trichothecinol A(10) represents a potential anticancer agent.
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| Keywords
Engleromyces goetzii
Trichothecene
Engleromycone
Cuparane
Infuscol
Mycotoxin
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| Fund:This work was supported by the National Natural Sciences Foundation of China(U1132607, 21302194), the National Science & Technology Pillar Program of China(2012BAD23B0305 and 2013BAI11B02). |
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Issue Date: 11 February 2018
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