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New Diterpenes from Cultures of the Fungus Engleromyces goetzii and Their CETP Inhibitory Activity |
| Yang Wang1,2, Ling Zhang1, Fang Wang1,2, Zheng-Hui Li1, Ze-Jun Dong1, Ji-Kai Liu1 |
1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2. University of Chinese Academy of Sciences, Beijing 100049, China |
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Abstract One new cleistanthane-type diterpene named engleromycenolic acid A(1), one new rosane-type diterpene named engleromycenolic acid B(2) and one new natural rosane-type diterpene, engleromycenol(3), along with three known rosanetype diterpenes, rosololactone(4), rosenonolactone(5) and 7-deoxyrosenonolactone(6) were isolated from cultures of the fungus Engleromyces goetzii, where it naturally grows on Alpine bamboo culms. The new compounds were elucidated based on their spectroscopic data. In addition, compounds 1-6 were evaluated for their cholesterol ester transfer protein(CETP) inhibition activity. This paper reports the isolation, structural elucidation, and CETP inhibition activity of these compounds.
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| Keywords
Engleromyces goetzii
Engleromycenolic acid A
Engleromycenolic acid B
Engleromycenol
CETP
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| Fund:This work was financially supported by the National Science&Technology Pillar Program of China(2012BAD23B0305 and 2013BAI11B02), the National Natural Sciences Foundation of China(U1132607, 21302194). |
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Issue Date: 11 February 2018
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