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Limonoid and Steroidal Saponin from Azadirachta indica |
| Lu Liu1,2, Yun-Li Zhao1, Gui-Guang Cheng3, Ying-Ying Chen1,2, Xu-Jie Qin1,2, Chang-Wei Song1,2, Xing-Wei Yang1,2, Ya-Ping Liu1, Xiao-Dong Luo1 |
1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2. University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3. Yunnan Institute of Food Safety, Kunming University of Science and Technology, Kunming 650500, People's Republic of China |
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Abstract A new limonoid, 17-(5-methoxy-2-oxofuran-3-yl)-28-deoxonimbolide(1), and a new C21 steroidal saponin, 2α, 4α-dihydroxy-pregn-5-en-16-one-3α-O-D-glucopyranoside(2), together with 11 known compounds were isolated from the methanol extract of the leaves of Azadirachta indica. The structures were elucidated by means of spectroscopic analysis and putative biosynthetic origins. All the compounds were evaluated for their antibacterial activities against six bacterial strains.
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| Keywords
Azadirachta indica
Limonoid
Steroidal saponin
Antibacterial activities
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| Fund:The authors are grateful to the Natural Science Foundation of China(81225024), the National Science and Technology Support Program of China(2013BAI11B02), for partial financial support, and to the analytical group of the Laboratory of Phytochemistry, Kunming Institute of Botany, for the spectral measurement. |
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Issue Date: 11 February 2018
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