Diprenylated Indole Alkaloids from Fruits of <i>Hexalobus monopetalus</i>

doi:10.1007/s13659-014-0010-x

Natural Products and Bioprospecting

2014, Vol. 4

Issue (2) : 101-105 DOI: 10.1007/s13659-014-0010-x

Original article

Diprenylated Indole Alkaloids from Fruits of Hexalobus monopetalus

Hamisi M. Malebo¹, Stephan A. Jonker², Reiner Waibel³, Mayunga H. H. Nkunya²

1. Department of Traditional Medicine Research, National Institute for Medical Research, P. O. Box 9653, Dar es Salaam, Tanzania;
2. Department of Chemistry, University of Dar es Salaam, P. O. Box 35061, Dar es Salaam, Tanzania;
3. Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of Erlangen, Schuhstrasse 19, 91052 Erlangen, Germany

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Abstract New hexalobine type alkaloid, 5-(2", 3"-epoxy-3"-methylbutyl)-3-(3'-hydroxy-3'-methyl-1'-acetyloxy-but-2'-yl) indole(1) alongside the known hexalobines 3-(2', 3'-dihydroxy-3'-methylbutyl)-5-(3"-methylcrotonoyl) indole(2), 3, 5-hexalobine C(3) and 3, 5-hexalobine D(4) were isolated from fruits of Hexalobus monopetalus. Compounds 3 and 4 exhibited antifungal activity against Candida albicans.

Keywords Hexalobus monopetalus Hexalobines Indole alkaloids Candida albicans

Fund:The Norwegian Agency for International Development(NORAD) through the NORAD Chemistry Project is appreciated for supporting this work through a scholarship grant to H. M. M. The National Institute for Medical Research(NIMR), The Department of Chemistry at the University of Dar es Salaam in Tanzania and the Department of Pharmaceutical Chemistry in the Institute of Pharmacy at Erlangen University in Germany are thanked for supporting the research project.

Issue Date: 11 February 2018

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Hamisi M. Malebo,Stephan A. Jonker,Reiner Waibel, et al. Diprenylated Indole Alkaloids from Fruits of Hexalobus monopetalus[J]. Natural Products and Bioprospecting, 2014, 4(2): 101-105.

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http://npb.kib.ac.cn/EN/10.1007/s13659-014-0010-x OR http://npb.kib.ac.cn/EN/Y2014/V4/I2/101

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7. H. Achenbach, M. Lowel, Phytochemistry 40, 967 (1995)
8. D.H. Williams, I. Fleming, Spectroscopic Methods in Organic Chemistry, 4th edn. (McGraw-Hill Book Company, New Delhi, 1989)

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