Manuka honey: an emerging natural food with medicinal use

doi:10.1007/s13659-013-0018-7

Natural Products and Bioprospecting

2013, Vol. 3

Issue (4) : 121-128 DOI: 10.1007/s13659-013-0018-7

Review

Manuka honey: an emerging natural food with medicinal use

Seema PATEL^a, Simon CICHELLO^b,c

a San Diego State University, San Diego CA 92182-7455, United States;
b School of Life Sciences, La Trobe University, Melbourne VIC 3086, Australia;
c Key State Pu-erh Tea Laboratory, Yunnan Agricultural University, Kunming 650201, China

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Abstract The health value of honey is universally acknowledged from time immemorial. Manuka (Leptospermum scoparium) is a tree, indigenous to New Zealand and South East Australia, and from the myrtle family, Myrtaceae. The honey produced from its flowers is a uni-floral honey largely produced in New Zealand. It is becoming increasingly popular as a functional food, seen in the aisles of health stores as its displays superior nutritional and phytochemistry profile over other varieties of honey. Examining existing research databases revealed its biological properties ranging from anti-oxidant, anti-inflammatory, anti-bacterial, anti-viral, anti-biotic and wound healing to immune-stimulatory properties. Methylglyoxal is the unique compound in the honey responsible for some of its potent anti-microbial properties. Further, propolis another component of honey contains chiefly flavonoids (i.e. galangin, pinocembrin), phenolic acids and their esters that may also contribute to its immuno-stimulant properties. Recent findings of the biological roles have been discussed with emphasis on the underlying mechanisms. The hurdles associated in its development as a functional food and also nutraceutical with future scopes have also been mentioned. Relevant data published in MEDLINE, Cochrane library, and EMBASE in the past decade have been gathered to formulate this review.

Keywords manuka honey methylglyoxal antimicrobial wound therapy anti-ulcer agent

Issue Date: 11 February 2018

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Seema PATEL,Simon CICHELLO. Manuka honey: an emerging natural food with medicinal use[J]. Natural Products and Bioprospecting, 2013, 3(4): 121-128.

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http://npb.kib.ac.cn/EN/10.1007/s13659-013-0018-7 OR http://npb.kib.ac.cn/EN/Y2013/V3/I4/121

[1]	Schneider, M.; Coyle, S.; Warnock, M.; Gow, I.; Fyfe, L. Phytother. Res. 2012, doi:10.1002/ptr.4844.
[2]	Tan, H. T.; Rahman, R. A.; Gan, S. H.; Halim, A. S.; Hassan, S. A.; Sulaiman, S. A.; Kirnpal-Kaur, B. S. BMC Complement. Altern. Med. 2009, 9, 34.
[3]	Shelock, O.; Dolan, A.; Athman, R.; Power, A.; Gethin, G.; Cowman, S.; Humpreys, H. BMC Complement. Altern. Med. 2010, 10, 47.
[4]	Anthimidou, E.; Mossialos, D. J. Med. Food 2013, 16, 42-47.
[5]	Bone, K. Phytother. Press, Warwick, QLD, Australia 2007.
[6]	Oddo, L.P.; Heard, T.A.; Rodriguez-Malaver, A.; Perez, R. A.; Fernandez-Muino, M.; Sancho, M. T.; Sesta, G.; Lusco, L.; Vit, P. J. Med. Food 2008, 11, 789-794.
[7]	Mao, W.; Schuler, M. A.; Berenbaum, M. R. Proc. Natl. Acad. Sci. USA 2013, 110, 8842-8846.
[8]	Zha, W. J.; Qian Y.; Shen, Y.; Du, Q.; Chen, F. F.; Wu, Z. Z.; Li, X.; Huang, M. Evid. Based Complement. Alternat. Med. 2013, 767689.
[9]	Wang, S. B.; Pang, S. B; Gao, M.; Fang, L. H; Du, G. H. Chin. J. Nat. Med. 2013, 11, 207-213.
[10]	Daher, S.; Gulacar, F. O. J. Agric. Food Chem. 2010, 56, 5775-5780.
[11]	Kato, Y.; Umeda, N.; Maeda, A.; Matsumoto, D.; Kitamoto, N.; Kikuzaki, H. J. Agric. Food Chem. 2012, 60, 3418-3423.
[12]	Jo, Y. H.; Kim, S. B.; Ahn, J. H.; Liu Q.; Hwang, B. Y.; Lee, M. K. Nat. Prod. Commun. 2013, 8, 481-483.
[13]	Curir, P.; Dolci, M.; Dolci P.; Lanzotti, V.; De Cooman, L. Phytochem. Anal. 2003, 14, 8-12.
[14]	Oelschlaegel, S.; Gruner, M.; Wang, P. N.; Boettcher, A.; Koelling-Speer, I.; Speer, K. J. Agric. Food Chem. 2012, 60, 7229-7237.
[15]	Kim J. H.; Chang, P. K.; Chan, K. L.; Faria, N. C.; Mahoney, N.; Kim, Y. K.; Martins Mde, L.; Campbell, B. C. Int. J. Mol. Sci. 2012, 11, 13867-13880.
[16]	Atrott, J.; Haberlau, S.; Henle, T. Carbohydr. Res. 2012, 361, 7-11.
[17]	Inoue, K.; Murayama, S.; Seshimo, F.; Takeba, K.; Yoshimura, Y.; Nakazawa, H. J. Sci. Food Agric. 2005, 85, 872-878.
[18]	Leong, A. G.; Herst, P. M.; Harper, J. L. Innate Immun. 2011, 18,459-466.
[19]	Keenan, J. I.; Salm, N.; Wallace, A. J.; Hampton, M. B. Phytother. Res. 2012, 26, 1620-1625.
[20]	Chepulis, L. M.; Francis, E. J. Complement. Integr. Med. 2012, 9, 1.
[21]	Alzahrani, H. A.; Alsabehi, R.; Boukraa, L.; Abdellah, F.; Bellik, Y.; Bakhotmah, B. A. Molecules 2012, 17, 10540-10549.
[22]	Wolbeling, F.; Munder, A.; Kerber-Momot, T.; Neumann, D.; Henning, C.; Hansen, G.; Tummler, B.; Baumann, U. Immunobiology 2011, 216, 901-908.
[23]	English, H. K.; Pack, A. R.; Molan, P. C. J. Int. Acad. Periodont. 2004, 6, 63-67.
[24]	Nayak, P. A.; Nayak, U. A.; Mythili, R. Contemp. Clin. Dent. 2010, 1, 214-217.
[25]	Badet, C.; Quero, F. Anaerobe 2011, 17, 19-22.
[26]	Stojicic, S.; Amorim, H.; Shen, Y.; Haapasalo, M. Int. Endod. J. 2013, 47, 649-659.
[27]	Cooper, R. A.; Molan, P. C.; Krishnamoorthy, L.; Harding, K. G. Eur. J. Clin. Microbiol. Infect. Dis. 2001, 20, 758-759.
[28]	Henriques, A. F.; Jenkins, R. E.; Burton, N. F.; Cooper, R. A. Eur. J. Clin. Microbiol. Infect. Dis. 2010, 29, 45-50.
[29]	Kilty, S. J.; Duval, M.; Chan, F. T.; Ferris, W.; Slinger, R. Int. Forum Allergy Rhinol. 2011, 1, 348-350.
[30]	Roberts, A. E.; Maddocks, S. E.; Cooper, R. A. Microbiology 2012, 158, 3005-3013.
[31]	Alzahrani, H. A.; Boukraa, L.; Bellik, Y.; Abdellah, F.; Bakhotmah, B. A.; Kolayli, S.; Sahin, H. Glob. J. Health Sci. 2012, 4, 191-196.
[32]	Packer, J. M.; Irish, J.; Herbert, B. R.; Hill, C.; Padula, M.; Blair, S. E.; Carter, D. A.; Harry, E. J. Int. J. Antimicrob. Agents 2012, 40, 43-50.
[33]	Maddocks, S. E.; Lopez, M. S.; Rowlands, R. S.; Cooper, R. A. Microbiology 2012, 158, 781-790.
[34]	Lin, S. M.; Molan, P. C.; Cursons, R. T. Eur. J. Clin. Microbiol. Infect. Dis. 2009, 28, 339-344.
[35]	Lin, S. M.; Molan, P. C.; Cursons, R. T. Eur. J. Clin. Microbiol. Infect. Dis. 2011, 30, 569-574.
[36]	Lu, J.; Carter, D. A.; Turnbull, L.; Rosendale, D.; Hedderley, D.; Stephens, J.; Gannabathula, S.; Steinhorn, G.; Schlothauer, R. C.; Whitchurch, C. B.; Harry, E. J. PLoS One 2013, 8, e55898.
[37]	Bang, L. M.; Buntting, C.; Molan, P. J. Altern. Complement. Med. 2003, 9, 267-273.
[38]	Majtan, J.; Bohova, J.; Horniackova, M.; Klaudiny, J.; Majtan, V. Phytother. Res. 2013, doi:10.1002/ptr.4957.
[39]	Jenkins, R. E.; Cooper, R. J. Antimicrob. Chemother. 2012, 67, 1405-1407.
[40]	Jenkins, R.; Cooper, R. PLoS One 2012, 7, e45600.
[41]	Muller, P.; Alber, D. G.; Turnbull, L.; Schlothauer, R. C.; Carter, D. A.; Whitchurch, C. B.; Harry, E. J. PLoS One 2013, 8, e57679.
[42]	Elkins, J. G.; Hassett, D. J.; Stewart, P. S.; Schweizer, H. P.; McDermott, T. R. Appl. Environ. Microbiol. 1999, 65, 4594-4600.
[43]	Shahzad, A.; Cohrs, R. J. Transl. Biomed. 2012, 3, 2.
[44]	Pesce, M.; Patruno, A.; Speranza, L.; Reale, M. Eur. Cytokine Netw. 2013, 24, 1-10.
[45]	Gethin, G. T.; Cowman, S.; Conroy, R. M. Int. Wound J. 2008, 5, 185-194.
[46]	Armstrong, D. G. Evid. Based Med. 2009, 14, 148.
[47]	Rudzka-Nowak, A.; Luczywek, P.; Gajos, M. J.; Piechota, M. Med. Sci. Monit. 2010, 16, 138-142.
[48]	Hampton, S.; Coulborn, A.; Tadej, M.; Bree-Aslan, C. Br. J. Nurs. 2011, 20, 38, 40-43.
[49]	Bischofberger, A. S.; Dart, C. M.; Perkins, N. R.; Kelly, A.; Jeffcott, L.; Dart, A. J. Vet. Surg. 2012, 42, 154-160.
[50]	Trudgian, J.; Trotman, S. Br. J. Nurs. 2011, 20, 10, 12, 14.
[51]	Thomas, M.; Hamdan, M.; Hailes, S.; Walker, M. J. Wound Care 2011, 20, 528, 530-533.
[52]	Ranzato, E.; Martinotti, S.; Burlando, B. Wound Repair. Regen. 2012, 20, 778-785.
[53]	Doerler, M.; Reich-Schupke, S.; Altmeyer, P.; Stucker, M. J. Dtsch. Dermatol. Ges. 2012, 10, 624-632.
[54]	Kim, J.; Kim, O. S.; Kim, C. S.; Sohn, E.; Jo, K.; Kim, J. S. Exp. Mol. Med. 2012, 44, 167-175.
[55]	Kamaratos, A. V.; Tzirogiannis, K. N.; Iraklianou, S. A.; Panoutsopoulos, G. I.; Kanellos, I. E.; Melidonis, A. I. Int. Wound J. 2012, PMID 22985336.
[56]	Sell, S. A.; Wolfe, P. S.; Spence, A. J.; Rodriguez, I. A.; McCool, J. M.; Petrella, R. L.; GArg, K.; Ericksen, J. J.; Bowlin, G. L. Int. J. Biomater. 2012, doi:10.1155/2012/313781
[57]	Tonks, A. J.; Cooper, R. A.; Jones, K. P.; Blair, S.; Parton, J.; Tonks, A. Cytokine 2003, 21, 242-247.
[58]	Hsiang, C. Y.; Hseu, Y. C.; Chang, Y. C.; Kuamr, K. J.; Ho, T. Y.; Yang, H. L. Food Chem. 2013, 136, 426-434.
[59]	Chepulis, L. M.; Francis, E. J. Complement. Integr. Med. 2012, 926.
[60]	Lu, J.; Randell, E.; Han, Y.; Adeli, K.; Krahn J.; Meng Q. H. Clin. Biochem. 2011, 44, 307-311.
[61]	Tonks, A. J.; Dudley, E.; Porter, N. G.; Parton, J.; Brazier, J.; Smith, E. L.; Tonks, A. J. Leukoc. Biol. 2007, 82, 1147-1155.
[62]	Fernandez-Cabezudo, M. J.; El-Kharrag, R.; Torab, F.; Bashir, G.; George, J. A.; El-Taji, H.; Al-Ramadi, B. K. PLoS One 2013, 8, e55993.
[63]	Radhika, M.; Ghoshal, N.; Chatterjee, A. Ind. J. Exp. Biol. 2012, 50, 491-496.
[64]	Bhandary, S.; Chaki, S.; Mukherjee, S.; Das, S.; Mukherjee, S.; Chaudhri, K.; Dastidar, S. G. Ind. J. Exp. Biol. 2012; 50, 491-496.
[65]	Majtan, J. Evid. Based Complement. Alternat. Med. 2011, 2011, ID 295494.
[66]	Rabbani, N.; Godfrey, L.; Xue, M.; Shaheen, F.; Geoffrion, M.; Milne, R.; Thornalley, P. J. Diabetes 2011, 60, 1973-1980.
[67]	Li, Y. C.; Tsai, S. H.; Chen, S. M.; Chang, Y. M.; Huang, T. C.; Huang, Y. P.; Chang, C. T.; Lee, J. A. Biochem. Biophys. Res. Commun. 2012, 423, 832-837.
[68]	Aron, M.; Victoria Akinpelu, O.; Dorion, D.; Daniel, S. Head Neck Surg. 2012, 41, 21-30.
[69]	Maletta, A. B.; Were, L. M. J. Food Sci. 2012, 77, 135-141.

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