Five new polyketides from the basidiomycete <i>Craterellus odoratus</i>

doi:10.1007/s13659-012-0057-5

Natural Products and Bioprospecting

2012, Vol. 2

Issue (4) : 170-173 DOI: 10.1007/s13659-012-0057-5

Regular Article

Five new polyketides from the basidiomycete Craterellus odoratus

Hua GUO^a,b,c, Tao FENG^a, Zheng-Hui LI^a, Ji-Kai LIU^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b School of Chemistry and Life Science, Anshan Normal College, Anshan 114005, China;
c Graduate University of Chinese Academy of Sciences, Beijing 100049, China

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Abstract Five new polyketides, craterellones A-E(1-5), were isolated from cultures of basidiomycete Craterellus odoratus, together with five known compounds(6-10). Structures of 1-5 were elucidated on the basis of extensive spectroscopic analysis. All compounds were evaluated for their inhibitory activities against one isozyme of 11β-hydroxysteroid dehydrogenase(11β-HSD1) and cytotoxic activities on five tumor cell lines. Compound 10 exhibited significant cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW-480, with IC₅₀ values of 0.50, 0.69, 0.64, 1.10, 0.54 μM, respectively.

Keywords Craterellus odoratus craterellones polyketides

Fund:This work was financially supported by National Basic Research Program of China(973 Program, 2009CB522300), the National Natural Science Foundation of China(30830113, U1132607).

Issue Date: 11 February 2018

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Hua GUO,Tao FENG,Zheng-Hui LI, et al. Five new polyketides from the basidiomycete Craterellus odoratus[J]. Natural Products and Bioprospecting, 2012, 2(4): 170-173.

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http://npb.kib.ac.cn/EN/10.1007/s13659-012-0057-5 OR http://npb.kib.ac.cn/EN/Y2012/V2/I4/170

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