| ORIGINAL ARTICLES |
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Setosphlides A-D, New Isocoumarin Derivatives from the Entomogenous Fungus Setosphaeria rostrate LGWB-10 |
| Wenbin Gao, Xiaoxia Wang, Fengli Chen, Chunqing Li, Fei Cao, Duqiang Luo |
| College of Life Science, Institute of Life Science and Green Development, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding 071002, China |
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Abstract Investigation of the entomogenous fungus Setosphaeria rostrate LGWB-10 from Harmonia axyridis led to the isolation of four new isocoumarin derivatives, setosphlides A-D (1-4), and four known analogues (5-8). Their planar structures and the relative configurations were elucidated by comprehensive spectroscopic methods. The absolute configurations of isocoumarin nucleus for 1-4 were elucidated by their ECD spectra. The C-10 relative configurations for the pair of C-10 epimers (1 and 2) were established by comparing the magnitude of the computed 13C NMR chemical shifts (Δδcalcd.) with the experimental 13C NMR values (Δδexp.) for the epimers. All of the isolated compounds (1-8) were evaluated for their cytotoxicities against four human tumor cell lines MCF-7, MGC-803, HeLa, and Huh-7.
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| Keywords
Entomogenous fungus
Setosphaeria rostrate
Isocoumarin
Absolute configuration
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| Fund:This work was funded by the National Natural Science Foundation of China (31672070) and National Key Research and Development Program of China (2017YFD0201400 and 2017YFD0201401), and the High Performance Computer Center of Hebei University. |
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Corresponding Authors:
Fei Cao, Duqiang Luo
E-mail: caofei542927001@163.com;duqiangluo@163.com
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Issue Date: 11 March 2021
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