New Iboga-Type Indole Alkaloids from <i>Tabernaemontana divaricata</i>

doi:10.1007/s13659-019-00226-z

Natural Products and Bioprospecting

2019, Vol. 9

Issue (6) : 425-429 DOI: 10.1007/s13659-019-00226-z

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New Iboga-Type Indole Alkaloids from Tabernaemontana divaricata

Xiang-Mei Li^1,2, Xian-Jun Jiang^1,2, Guo-Zhu Wei^1,2, Li-Hua Ren^1,2, Li-Xia Wang^1,2, Xue-Lian Cheng^1,3, Fei Wang^1,2

1 BioBioPha Co., Ltd., Kunming 650201, People's Republic of China;
2 Reference Substance Branch, National Engineering Research Center for Modernization of Traditional Chinese Medicine, Kunming 650201, People's Republic of China;
3 Department of Pharmacy, The People's Hospital of Fengjie County, Chongqing 404600, People's Republic of China

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Abstract Two hitherto unknown iboga-type indole alkaloids, namely (3R)-7,19-di-epi-3-methoxytabernoxidine (1) and (3R,19R)-19-hydroxy-3-(2-oxopropyl)voacangine (2), together with eight known alkaloids (3-10), were isolated from the twigs and leaves of Tabernaemontana divaricata. Their structures were established on the basis of spectroscopic data interpretation, single crystal X-ray diffraction analysis and circular dichroism spectrum.

Keywords Tabernaemontana divaricata Iboga-type indole alkaloid Single crystal X-ray diffraction

Fund:This work was financially supported by the "Large-scale Compound Library" project of National Development and Reform Commission of China.

Corresponding Authors: Fei Wang E-mail: f.wang@mail.biobiopha.com

Issue Date: 11 December 2019

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Xiang-Mei Li,Xian-Jun Jiang,Guo-Zhu Wei, et al. New Iboga-Type Indole Alkaloids from Tabernaemontana divaricata[J]. Natural Products and Bioprospecting, 2019, 9(6): 425-429.

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http://npb.kib.ac.cn/EN/10.1007/s13659-019-00226-z OR http://npb.kib.ac.cn/EN/Y2019/V9/I6/425

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[1]	Yan Deng, Mei-Fen Bao, Bao-Bao Shi, Jing Wu, Xiang-Hai Cai. Three New Indole Alkaloids from Tabernaemontana divaricata[J]. Natural Products and Bioprospecting, 2018, 8(3): 183-188.

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